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Table 3 Association of atherosclerotic plaques and stenosis with UAE and eGFR

From: Albuminuria but not low eGFR is closely associated with atherosclerosis in patients with type 2 diabetes: an observational study

 

UAE

eGFR

OR (95% CI)

p values

OR (95% CI)

p values

Plaques

 Model 1

1.22 (1.11–1.35)

 < 0.001

0.49 (0.44–0.54)

 < 0.001

 Model 2

1.16 (1.03–1.30)

0.017

0.90 (0.79–1.02)

0.098

 Model 3

1.19 (1.05–1.35)

0.007

0.88 (0.77–1.01)

0.059

 Model 4

1.15 (1.00–1.32)

0.046

0.88 (0.76–1.02)

0.079

 Model 5

1.20 (1.03–1.39)

0.020

0.88 (0.75–1.02)

0.089

Stenosis

 Model 1

1.30 (1.17–1.45)

 < 0.001

0.61 (0.54–0.68)

 < 0.001

 Model 2

1.27 (1.13–1.43)

 < 0.001

1.04 (0.91–1.18)

0.614

 Model 3

1.26 (1.11–1.42)

 < 0.001

1.04 (0.91–1.19)

0.593

 Model 4

1.22 (1.07–1.39)

0.003

1.08 (0.93–1.25)

0.312

 Model 5

1.17 (1.01–1.35)

0.036

1.12 (0.95–1.31)

0.177

  1. UAE urinary albumin excretion, eGFR estimated glomerular filtration rate, DD duration of diabetes, APA anti-platelet agents, LLD lipid-lowering drugs, AHA anti-hypertensive agents, SBP systolic blood pressure, DBP diastolic blood pressure, WC waist circumference, WHR waist-to-hip ratio, BMI body mass index, FPG fasting plasma glucose, 2-h PPG 2-h postprandial plasma glucose, HbA1c glycated hemoglobin A1c, FCP fasting C-peptide, 2-h PCP 2-h postprandial C-peptide, HOMA2-IR HOMA of insulin resistance, TG total triglycerides, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ALT alanine transaminase, SUA serum uric acid
  2. Model 1: unadjusted
  3. Model 2: Adjusted for age, sex, DD, hypertension, smoking status and alcohol use
  4. Model 3: Further adjustment for use of AHA, LLD, APA
  5. Model 4: Further adjustment for SBP, DBP, BMI, WC and WHR
  6. Model 5: Further adjustment for ALT, TG, TC, HDL-C, LDL-C, SUA, FPG, 2-h PPG, HbA1c, FCP, 2-h PCP, HOMA2-IR