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Table 2 Characteristics of the subjects according to eGFR levels

From: Albuminuria but not low eGFR is closely associated with atherosclerosis in patients with type 2 diabetes: an observational study

Variables eGFR ≥ 90ml/min/1.73m2 (n = 1684) eGFR 60–89 ml/min/1.73m2 (n = 719) eGFR < 60ml/min/1.73m2 (n = 162) p value p* value
Male (n, %) 930 (55.2%) 410 (57.0%) 88 (54.3%) 0.674 < 0.001
Age (years) 56 ± 12 66 ± 10 69 ± 10 < 0.001 < 0.001
DD (months)* 72 (12–120) 96 (36–156) 120 (60–192) < 0.001 0.234
Hypertension (n, %) 788 (46.8%) 456 (63.4%) 132 (81.5%) < 0.001 < 0.001
Drinking (n, %) 287 (17.0%) 100 (13.9%) 10 (6.2%) < 0.001 0.025
Smoking (n, %) 520 (30.9%) 185 (25.7%) 33 (20.4%) 0.002 0.358
APA (n, %) 789 (46.9%) 436 (60.6%) 92 (56.8%) < 0.001 0.066
LLD (n, %) 509 (30.2%) 234 (32.5%) 56 (34.6%) 0.332 0.093
AHA (n, %) 700 (41.6%) 434 (60.4%) 126 (77.8%) < 0.001 < 0.001
IIA (n, %) 1209 (71.8%) 491 (68.3%) 146 (90.1%) < 0.001 < 0.001
Metformin (n, %) 993 (59.0%) 378 (52.6%) 73 (45.1%) < 0.001 0.016
Insulin sensitizers (n,%) 258 (15.3%) 97 (13.5%) 22 (13.6%) 0.464 0.642
SBP (mmHg) 130 ± 17 134 ± 18 141 ± 21 < 0.001 < 0.001
DBP (mmHg) 80 ± 10 80 ± 10 80 ± 11 < 0.001 0.918
WC (cm) 88.62 ± 10.24 90.25 ± 10.32 92.51 ± 9.67 < 0.001 < 0.001
WHR 0.91 ± 0.06 0.91 ± 0.07 0.93 ± 0.06 < 0.001 0.009
BMI (kg/m2) 24.7 ± 3.48 25.13 ± 3.21 25.74 ± 3.69 < 0.001 < 0.001
FPG (mmol/l)* 8.07 (6.48–10.04) 7.27 (5.9-9) 7.06 (5.62–8.89) < 0.001 < 0.001
2-h PPG (mmol/l)* 13.81 (10.51–17.17) 13.14 (9.66–16.49) 12.15 (9.58–16.94) 0.005 0.137
HbA1c (%) 9.34 ± 2.34 8.79 ± 2.29 8.81 ± 2.69 0.150 < 0.001
FCP (ng/mL)* 1.58 (0.94–2.33) 1.7 (1.1–2.53) 2.21 (1.2–3.58) < 0.001 < 0.001
2-h PCP (ng/mL)* 3.46 (1.88–5.18) 4.12 (2.43–5.53) 4.18 (2.32–5.82) < 0.001 < 0.001
HOMA2-IR* 1.4 (0.8-2) 1.4 (0.9–2.1) 2 (0.9–2.9) 0.050 < 0.001
TG (mmol/l)* 1.43 (0.99–2.14) 1.42 (1–2.03) 1.55 (1.08–2.39) 0.512 < 0.001
TC (mmol/l) 4.73 ± 1.1 4.67 ± 1.08 4.97 ± 1.45 < 0.001 0.001
HDL-C (mmol/l) 1.12 ± 0.3 1.11 ± 0.3 1.06 ± 0.3 < 0.001 < 0.001
LDL-C (mmol/l) 3.14 ± 0.95 3.07 ± 0.93 3.2 ± 1.08 < 0.001 0.251
ALT (U/l)* 20 (14–31) 19 (13–27) 16 (12–26) 0.006 0.607
SUA (µmol/l) * 292 (244–351) 330 (278–391) 414 (349–495) < 0.001 < 0.001
  1. Values are expressed as the mean ± S.D, or median with interquartile range, or percentages
  2. eGFR estimated glomerular filtration rate, DD duration of diabetes, APA anti-platelet agents, LLD lipid-lowering drugs, AHA anti-hypertensive agents, IIA insulin or insulin analogue, SBP systolic blood pressure, DBP diastolic blood pressure, WC waist circumference, WHR waist-to-hip ratio, BMI body mass index, FPG fasting plasma glucose, 2-h PPG 2-h postprandial plasma glucose, HbA1c glycated hemoglobin A1c, FCP fasting C-peptide, 2-h PCP 2-h postprandial C-peptide, HOMA2-IR HOMA of insulin resistance, TG total triglycerides, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ALT alanine transaminase, SUA serum uric acid
  3. p value: The p-values were not adjusted for sex and age for the trend
  4. p* value: The p-values were adjusted for sex and age for the trend
  5. * The Kruskal-Wallis test was applied