Acute glycemic variability and risk of mortality in patients with sepsis: a meta-analysis

Li, Xiaofei; Zhang, Daofu; Chen, Yongxin; Ye, Weiwei; Wu, Shuang; Lou, Lianqing; Zhu, Yanshuang

doi:10.1186/s13098-022-00819-8

Diabetology & Metabolic Syndrome

Table 1 Characteristics of the included cohort studies

From: Acute glycemic variability and risk of mortality in patients with sepsis: a meta-analysis

Study	Design	Country	Clinical setting	Diagnostic criteria for sepsis	Sample size	Mean age (years)	Male (%)	DM (%)	GV measurements and cutoff	Duration for GV measurements	Follow-up duration	Death cases	Variables adjusted
Waeschle 2008	PC	Germany	ICU	Sepsis 1.0	191	68	58	29	SDBG (1.1 mmol/l)	During ICU stay	Within hospitalization	46	None
Ali 2008	RC	USA	ICU or general ward	Sepsis 2.0	1246	60	52	32	GLI (medians)	During hospitalization	Within hospitalization	344	Age, sex, hypoglycemia, DM, RF, insulin use, and number of organ failures
Ge 2013	RC	China	ICU	Sepsis 2.0	111	67	70	NR	SDBG, MAGE, and GLI (medians)	During ICU stay	28 days	39	Age and APACHE II score
Wang 2014	RC	China	ICU	Sepsis 1.0	196	59	51	NR	SDBG (median)	During ICU stay	28 days	92	Age, SOFA score at admission, insulin dose, MV, and number of organ failures
Chao 2017	RC	China	ED	Sepsis 3.0	1537	66	54	58	CVBG (30%)	During hospitalization	Within hospitalization	437	Age, sex, DM, comorbidities, BG at admission, and infection sites
Leung 2019	RC	China	ICU or general ward	Sepsis 3.0	317	66	64	46	CVBG (40%)	During hospitalization	Within hospitalization	116	None
Chao 2020	RC	China	ICU	Sepsis 3.0	452	71	77	35	MAGE (3.6 mmol/l) and CVBG (30%)	During ICU stay	30 days	140	Age, sex, HbA1c, severe hypoglycemic episodes, cerebrovascular disease, hemoglobin and creatinine, and APACHE II score
Xu 2021	RC	China	ICU	Sepsis 3.0	73	73	34	NR	MAGE, SDBG, and GLI (medians), and CVBG (30%)	During ICU stay	28 days	18	Age and APACHE II score
Furushima 2021	PC	Japan	ICU	Sepsis 3.0	40	70	88	NR	MAGE (median)	First 48 h in ICU	90 days	11	Age, DM, and APACHE II score
Sun 2021	RC	China	ICU	Sepsis 3.0	133	73	65	24	SDBG (median) and CVBG (20%)	First 6 h in ICU	Within hospitalization	46	Age, SCr at admission, and APACHE II score

DM, diabetes mellitus; GV, glycemic variability; PC, prospective cohort; RC, retrospective cohort; ICU, intensive care unit; ED, emergency department; NR, not reported; SDBG, standard deviation of blood glucose; GLI, glycemic lability index; MAGE, mean amplitude of glycemic excursion; CVBG, coefficient of variation of blood glucose; RF, renal failure; APACHE II, the Acute Physiology and Chronic Health Evaluation II; SOFA, Sequential Organ Failure Assessment; BG, blood glucose; SCr, serum creatinine; HbA1c, glycated hemoglobulin;

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ISSN: 1758-5996

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