Fig. 3
High level FSH, not low estrogen, increased the mouse serum rennin levels and BP. The serum FSH (A), LH (B), E2 (C), rennin (D) and angiotensin (E) in different treatment groups. The SBP (F), DBP (G), MAP (H) and HR (I) in different treatment groups. Data are presented as mean ± SEM. 10 mice/group, *P < 0.05, **P < 0.01, ***P < 0.001, compared with the corresponding controls. ns, not significant. S, sham group; O, OVX (ovariectomized mice); O + G (ovariectomized mice injected with GnRHa); O + E + F (ovariectomized mice injected with estrogen and FSH). P-values for panel A were 0.00026, 0.00018, respectively. P-value for panel B was 0.0318. P-values for panel C were 0.00054, 0.00032, respectively. P-values for panel D were 0.0065, 0.0047, respectively. P-values for panel E were 0.0266, 0.0187, respectively. P-values for panel F were 0.0412, 0.0375, respectively. P-values for panel G were 0.0306, 0.0285, respectively. P-values for panel H were 0.0446, 0.0349, respectively. P-values for panel I were 0.0415, 0.0307, respectively