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Table 3 Clinical and laboratory tests of 5 diabetic ketoacidosis with hemolysis children at the time of hemolysis occurs

From: Glucose-6-Phosphate dehydrogenase deficiency associated hemolysis in a cohort of new onset type 1 diabetes children in Guangdong province, China

Patient

1

2

3

4

5

Normal range

Age at onset

9y

2y8m

3y

13y

1y8m

 

Gender

F

M

M

M

M

 

Symptoms

Pallor

Pallor

Cola-colored urine

Jaundice

Cola-colored urine

 

Hemoloysis occurs after admission(d)

2

7

2

4

7

 

HGB (g/L)

98

103

85

100

87

105–145

Ret (%)

6.8

10.9

6.2

6.1

4.5

0.5–1.5

WBC (× 109/L)

5.9

6.2

8.3

8.3

17.0

5–12

CRP (mg/L)

1.25

2.21

1.91

1.29

0.08

 < 8.2

FPG (mmol/L)

7.2

13.3

11.2

9.4

8.7

3.9–6.1

TBIL (umol/L)

24.2

40.0

20.8

130.5

34.2

2–17

IBIL (umol/L)

18.8

31.0

16

124.5

25.5

2–13.7

ALT (U/L)

16

20

16

21

28

9–50

LDH (U/L)

336

357

420

178

213

159–322

BUN (mmol/L)

2.9

2.8

2.5

3.1

4.1

2.7–7.1

Coombs test

–

–

–

–

–

–

Urobilinogen

 + 

 + 

 + 

 +  + 

 +  + 

–

pH

7.43

7.45

7.35

7.33

7.4

7.31–7.41

HCO3 (mmol/L)

22

22.5

20.2

22.9

22.3

18.6–22.6

Plasma osmolality (mOsm/kg)

293

285

295

290

291

285–295

G6PD/6PGD

0.12

0.10

0.12

0.26

0.06

1.0–2.3

G6PD gene

c.1388G > A

c.1376G > T

c.95A > G

Not detected

c.1388G > A

 
  1. HGB hemoglobin, Ret reticulocyte, WBC white blood cells count, CRP c-reactive protein, FPG fasting plasma glucose, TBIL total bilirubin, IBIL indirect bilirubin, ALT alanine aminotransferase, LDH lactate dehydrogenase, BUN blood urea nitrogen, G6PD glucose-6-phosphate dehydrogenase, 6PGD 6-phosphogluconate dehydrogenase