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Table 6 Follow-up changes in metabolic biomarkers after chemotherapy among early stage breast cancer patients

From: Metabolic syndrome and breast cancer survivors: a follow-up analysis after completion of chemotherapy

Variable

Pre-treatmenta

Post-treatmenta

Follow-upa

% Change+

P+

Lipid profile

 Total cholesterol, mg/dL

185.5 (48.3)

201.9 (45.5)

225.8 (56.1)

10.6

< 0.01

 LDL-C, mg/dL

100.5 (34.4)

111.1 (43.7)

134.5 (45.8)

17.4

< 0.01

Glucose metabolism

 Fasting insulin, mIU/mL

18.9 (21.8)

32.6 (17.3)

36.9 (15.4)

11.7

< 0.01

 HOMA-IR

4.52 (1.1)

9.4 (1.5)

11.4 (1.3)

17.5

< 0.01

 HbA1c, %

5.4 (0.4)

5.9 (0.6)

6.7 (0.8)

11.9

< 0.01

Inflammation

 CRP, mg/L

0.37 (0.36)

0.49 (0.21)

0.65 (0.2)

24.6

< 0.01

  1. LDL-C low-density lipoprotein-cholesterol, HOMA-IR homeostatic model assessment-insulin resistance, HbA1c glycosylated hemoglobin, CRP C-reactive protein
  2. aMean (± SD)
  3. +From post-treatment to follow-up