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Fig. 7 | Diabetology & Metabolic Syndrome

Fig. 7

From: Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway

Fig. 7

The effect of TRL on apoptosis in HMCs. A Representative flow cytometry graphs are shown. Early apoptotic cells are located in the grid, and the numbers above them represent the percentage of apoptotic cells. B DNA fragmentation in HMCs detected by TUNEL (×200). Cells that were positive for terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end-labeling (TUNEL) exhibited red staining in the nucleus. DAPI solution was used to stain nuclei (blue). NG normal glucose, HG high glucose, A TRL + high glucose, B TRL + β-catenin siRNA + high glucose, C β-catenin pcDNA + high glucose, D TRL + β-catenin pcDNA + high glucose, E ICG-001 + high glucose; ##P < 0.01 versus NG; *P < 0.05 versus HG, **P < 0.01 versus HG, △P < 0.05 versus A; ▲▲P < 0.01 versus C

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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