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Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway

Fig. 5

Expression of β-catenin, TCF4, Wnt5a, Wnt4, and GSK-3β in HMCs. After treatment, proteins were extracted from the cells and assessed by western blot analysis. GAPDH served as the loading control. A Representative western blot of β-catenin, TCF4, Wnt5a, Wnt4, and GSK-3β expression. B The relative β-catenin, TCF4, and Wnt5a protein expression detected by western blot. NG normal glucose, HG high glucose, A TRL + high glucose, B TRL + β-catenin siRNA + high glucose, C β-catenin pcDNA + high glucose, D TRL + β-catenin pcDNA + high glucose, E ICG-001 + high glucose; #P < 0.05 versus NG, ##P < 0.01 versus NG; *P < 0.05 versus HG, **P < 0.01 versus HG; P < 0.01 versus group A, P < 0.01 versus group A; P < 0.05 versus group C, ▲▲P < 0.01 versus group C

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