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Table 2 Association of HNF1A variants with metabolic syndrome traits in the studied Tunisian population

From: Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

 

rs1169288

rs2464196

rs735396

AA + AC

CC

p-value

p-value*

GG + GA

AA

p-value

p-value*

TT + TC

CC

p-value

p-value*

WC (cm)

101.6

102.3

0.65

1

101.6

105.3

0.035a

0.105

101.5

104.3

0.013a

0.039a

BMI (kg/m2)

30.05

30.17

0.99

1

29.93

30.68

0.1

0.3

29.94

30.35

0.35

1

FPG (mmol/l)

7.81

8.68

0.1

0.3

7.8

8.36

0.47

1

7.9

7.88

0.85

1

SBP (mmHg)

14.01

13.81

0.48

1

13.95

14.11

0.62

1

13.98

13.95

0.72

1

DBP (mmHg)

8.08

8.08

0.99

1

8.07

8.08

0.61

1

8.11

7.97

0.27

0.81

TC (mmol/l)

5.09

5.31

0.056

0.168

5.08

5.30

0.056

0.168

5.11

5.13

0.83

1

HDL (mmol/l)

1.30

1.38

0.07

0.21

1.3

1.37

0.037a

0.111

1.29

1.36

0.08

0.24

LDL (mmol/l)

3.24

3.31

0.61

1

3.23

3.34

0.45

1

3.24

3.25

0.9

1

TG (mmol/l)

1.66

1.76

0.5

1

1.66

1.71

0.96

1

1.66

1.69

0.8

1

  1. Data are presented as means. Linear regression, adjusted for age, sex and BMI, was used to assess genotype phenotype correlations under the recessive model of inheritance
  2. BMI Body Mass Index, DBP diastolic blood pressure, FPG fasting plasma glucose, HDL high density lipoprotein cholesterol, LDL low density lipoprotein cholesterol, SBP systolic blood pressure, TC total cholesterol, TG Triglycerides, WC waist circumference
  3. aIndicated a significant result
  4. p-value*: p-values after Bonferroni correction
  5. For the Bonferroni correction, p-values were multiplied by 3 (the number of SNPs in our study)
  6. Calculations were performed using SNPassoc R package
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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