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Table 2 Comparison of changes ▀ in liver enzymes, anthropometry measurements, and physical activity between the groups

From: Curcumin and zinc co-supplementation along with a loss-weight diet can improve lipid profiles in subjects with prediabetes: a multi-arm, parallel-group, randomized, double-blind placebo-controlled phase 2 clinical trial

Variables Groups p Adjusted P*
Placebo
N = 20
Curcumin
N = 21
Zinc
N = 21
Zinc and curcumin
N = 20
Alanine transaminase (IU/L) − 0.7 ± 2.96 − 1.05 ± 3.93 − 1.19 ± 3.17 − 1.1 ± 3.23 0.968 0.918
Aspartate transaminase (IU/L) 0.05 ± 2.48 − 0.8 ± 2.48 − 0.09 ± 2.39 0 ± 3.31 0.708 0.426
Weight (kg) − 2.59 ± 2.45 − 4.88 ± 3.14b − 4.88 ± 2.63b − 5.79 ± 2.77c 0.004 0.004
Body mass index (kg/m2) − 0.92 ± 0.85 − 1.96 ± 1.299b − 1.85 ± 1.01b − 2.09 ± 1.17c 0.004 0.006
Waist circumstance (cm) − 1.86 ± 2.12 − 3.84 ± 2.86 − 2.95 ± 3.35 − 3.16 ± 2.55 0.154 0.26
Hip circumstance (cm) − 2.345 ± 2.01 − 4.83 ± 4.16 − 4.08 ± 4.08 − 4.94 ± 3.37 0.081 0.161
Physical activity# (MET·min·wk−1) 22.75 (− 74.25, 346) 49.5 (− 738.75, 426) − 213 (− 213, 346.5) 198 (− 178.5, 532) 0.763 0.98
  1. MET·min·wk1: metabolic equivalent of task minute per week
  2. Data were presented as mean ± standard deviation or median (interquartile (IQR)) for normally and non-normally distributed data, respectively
  3. ▀The changes (pre-post intervention) calculated based on the difference of variables from the baseline (pre- intervention) to the end (post intervention) of the study
  4. P was calculated for the comparison variables between four groups using one-way analysis of variance (one-way ANOVA) with post hoc (LSD) analysis
  5. #P was calculated for the comparison variables between four groups using Kruskal–Wallis
  6. *Adjusted P-value was calculated using ANCOVA or nonparametric ANCOVA; Adjusted for physical activity levels at the baseline
  7. Significant changes with placebo group indicated by ap < 0.05, bp < 0.01, cp < 0.001