Fig. 4

Overexpression of FGD5-AS1 boosted growth and alleviated apoptosis and myocardial fibrosis, of high glucose-induced AC16 cells. A The level of FGD5-AS1 was confirmed through RT-qPCR in different groups. B CCK-8 assay showed that upregulation of FGD5-AS1 reversed the reduction of cell proliferation in AC16 cells caused by high glucose. C, D The levels of caspase-3, bcl2, bax, collagen-1, and collagen-3 were detected through RT-qPCR in AC16 cells. **P  < 0.01, ***P  < 0.001 (compared with mock). ^##P  < 0.01, ^###P  < 0.001 (compared with HG  +  ov-NC). HG high glucose