An early prediction model for gestational diabetes mellitus based on genetic variants and clinical characteristics in China

Table 3 Association of 4 SNPs with glucose metabolism-related indicators

SNP	A/a	FBG		1-h OGTT BG		2-h OGTT BG		HbA1c		HOMA-β		HOMA-IR
SNP	A/a	β (95% CI)	P	β (95% CI)	P	β (95% CI)	P	β (95% CI)	P	β (95% CI)	P	β (95% CI)	P
rs10830963	C/G	0.04 (− 0.01–0.09)	0.077	0.29 (0.11–0.47)	0.002	0.13 (− 0.04–0.29)	0.126	0.01 (− 0.03–0.04)	0.717	3.20 (− 40.56–46.96)	0.886	0.16 (0.03–0.29)	0.017
rs1436953	C/T	0.03 (− 0.02–0.08)	0.257	0.19 (0.00–0.38)	0.051	0.22 (0.05–0.39)	0.010	0.03 (0.00–0.07)	0.051	− 3.06 (− 47.48–41.36)	0.892	0.18 (0.04–0.31)	0.011
rs7172432	A/G	0.01 (− 0.04–0.06)	0.720	0.21 (0.03–0.40)	0.025	0.24 (0.07–0.41)	0.005	0.04 (0.00–0.07)	0.038	− 12.69 (− 56.45–31.08)	0.569	0.16 (0.02–0.29)	0.020
bs16955379	C/T	0.06 (0.00–0.11)	0.035	0.24 (0.04–0.43)	0.018	0.20 (0.03–0.38)	0.025	0.03 (− 0.01–0.06)	0.147	− 5.180 (− 50.25–39.90)	0.821	0.06 (− 0.08–0.19)	0.432

A/a: major allele/minor allele; Risk allele was underlined and in bold. FBG: fasting blood glucose; 1-h OGTT BG: OGTT blood glucose after 1 h; 2-h OGTT BG: OGTT blood glucose after 2 h; HbA1c: glycosylated hemoglobin; HOMA-β: homeostatic model assessments of islet β-cell function; HOMA-IR: homeostatic model assessments of insulin resistance
All analyses were adjusted for maternal age, gravidity, parity, BMI, family history of diabetes and way of conception in the linear regression model

ISSN: 1758-5996