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Fig. 4 | Diabetology & Metabolic Syndrome

Fig. 4

From: Circular RNA circZNF532 facilitates angiogenesis and inflammation in diabetic retinopathy via regulating miR-1243/CARM1 axis

Fig. 4

circZNF532 indirectly regulated CARM1 by binding to miR-1243. A The putative binding site of miR-1243 on CARM1 3′UTR was exhibited. B The interaction between miR-1243 and CARM1 was determined by dual-luciferase reporter assay. C and D CARM1 mRNA and protein levels in serum from DR patients (n = 23) and healthy controls (n = 23) were examined by qRT-PCR and western blot. E CARM1 protein expression was measured by western blot in hRMECs treated with NG or HG for different times. F CARM1 protein level was examined by western blot in hRMECs transfected with miR-NC or miR-1243. G hRMECs were introduced with si-NC, si-circZNF532, si-circZNF532 + in-miR-NC or si-circZNF532 + in-miR-1243, and CARM1 protein level was detected using western blot. *P < 0.05

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