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Table 4 Multiplicative and additive interactions between CSI and demographic and lifestyle characteristics

From: Association between life-course cigarette smoking and metabolic syndrome: a discovery-replication strategy

Stratified factors

Discovery stage: TNCHS study a

Replication stage: CHNS study b

MetS ( +)/All

CSI categories

Ptrendc

Pinteraction d

RERI

(95%Cl) e

MetS ( +)/All

CSI categories

P trend c

P interaction d

RERI

(95%Cl) e

Tertile 1

Tertile 2

Tertile 3

Tertile 1

Tertile 2

Tertile 3

OR (95%Cl)

OR (95%Cl)

OR (95%Cl)

OR (95%Cl)

OR (95%Cl)

OR (95%Cl)

Sex

     

0.245

0.31

(− 0.19 to 0.81)

     

0.312

− 0.07

(− 0.69 to 0.54)

 Female

1932/8149

1.19 (0.73–1.96)

1.78 (0.98–3.23)

1.33 (0.67–2.66)

0.050

755/4589

1.03 (0.53–2.01)

1.42 (0.67–3.03)

0.93 (0.45–1.93)

0.738

 Male

1614/7073

1.22 (0.95–1.56)

1.82 (1.46–2.28)

2.15 (1.72–2.69)

 < 0.001

804/3976

1.05 (0.80–1.36)

1.26 (1.00–1.60)

1.17 (0.91–1.50)

0.085

Age

     

0.015

− 0.35

(− 0.86 to 0.16)

     

0.001

− 1.29

(− 2.13 to − 0.45)

 < 70 years

1988/9544

1.25 (0.96–1.63)

1.87 (1.47–2.37)

2.31 (1.81–2.95)

 < 0.001

1313/7591

0.97 (0.76–1.24)

1.38 (1.09–1.76)

1.33 (1.03–1.71)

0.004

 ≥ 70 years

1558/5678

1.04 (0.71–1.52)

1.46 (0.99–2.15)

1.41 (0.95–2.08)

0.020

246/974

0.71 (0.29–1.75)

0.61 (0.27–1.37)

1.07 (0.62–1.84)

0.813

Exercise status

     

0.542

− 0.10

(− 0.29 to 0.49)

     

0.930

0.004

(− 0.32 to 0.31)

 Exercise/like

2334/9267

1.04 (0.80–1.35)

1.81 (1.42–2.30)

1.97 (1.54–2.53)

 < 0.001

462/2608

1.06 (0.72–1.57)

1.28 (0.87–1.90)

0.73 (0.47–1.15)

0.701

 No exercise /dislike

1212/5955

1.68 (1.13–2.50)

1.66 (1.12–2.47)

2.08 (1.43–3.01)

 < 0.001

1097/5957

1.44 (1.06–1.95)

1.31 (0.99–1.73)

1.11 (0.84–1.45)

0.180

Alcohol consumption

     

0.054

− 0.38

(− 0.83 to 0.07)

     

0.597

0.16

(− 0.15 to 0.46)

 Never consumed alcohol

3204/14,057

1.23 (0.92–1.65)

1.89 (1.43–2.50)

2.48 (1.86–3.30)

 < 0.001

1038/5799

1.15 (0.78–1.69)

1.35 (0.95–1.91)

0.88 (0.62–1.24)

0.839

 Past/current consumer

342/1165

1.02 (0.69–1.52)

1.37 (0.94–1.99)

1.44 (1.00–2.08)

0.038

521/2766

1.23 (0.89–1.70)

1.36 (1.00–1.86)

1.31 (0.94–1.82)

0.047

  1. CSI comprehensive smoking index, OR: odds ratio, CI confidence interval, BMI body mass index, RERI relative excess risk due to interaction
  2. aAdjusted for age, physical activity, BMI, dietary habits
  3. bAdjusted for sex, age, BMI, province, region
  4. cLinear trend tests were performed by entering the median value of each group of cigarette smoking variables as continuous variables in the models
  5. dP values for the multiplicative interactions between CSI and stratified factors
  6. eIn the calculation of RERI, smoking status was modeled as a dichotomous variable (never vs. ever)
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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