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Table 1 TLR9 knockdown function on the progression of DN in experimental mice (db/db)

From: TLR9 regulates NLRP3 inflammasome activation via the NF-kB signaling pathway in diabetic nephropathy

Indices

db/m

db/db

db/db + shRNA-NC

db/db + shRNA-TLR9

Body weight, g

21.31 ± 2.59

43.25 ± 5.06*

43.06 ± 6.01

32.62 ± 3.63#

Kidney weight, g

0.15 ± 0.03

0.25 ± 0.05*

0.24 ± 0.06

0.19 ± 0.03#

Blood glucose, mmol/L

6.99 ± 0.88

28.39 ± 3.65**

27.12 ± 3.85

19.63 ± 2.50#

SCR, μmol/L

35.12 ± 7.39

50.25 ± 5.20*

51.85 ± 5.75

41.05 ± 4.06#

BUN, mmol/L

8.70 ± 1.05

9.45 ± 0.96

9.40 ± 0.89

9.36 ± 0.93

Urinary albumin, μg/24 h

45.12 ± 13.75

693.75 ± 158.69***

720.15 ± 185.10

275.52 ± 56.82##

  1. db/m, nondiabetic mice; db/db, diabetic mice (mock-treated); db/db + shRNA-NC, experimental mice (db/db) treated with lentiviral-shRNA-NC at 100 mg per kg body weight; db/db + shRNA-TLR9, experimental mice (db/db) treated with lentiviral-shRNA-TLR9 at 100 mg per kg body weight
  2. Values are expressed as mean ± SD. SCR, serum creatinine; BUN, blood urea nitrogen. (*P < 0.05, **P < 0.01, ***P < 0.001 vs. db/m group; #P < 0.05, ##P < 0.01 vs. db/db + shRNA-NC group)