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Table 5 Subgroup analyses of the association between Cre/BW ratio and incident T2DM

From: Creatinine-to-body weight ratio is a predictor of incident diabetes: a population-based retrospective cohort study

Subgroup

N1 (< 0.86)

N2 (≥ 0.86, < 1.36)

N3 (≥ 1.36)

Cre/BW ratio (× 100)

P. for. interaction

Sex

    

0.026

 Women

     
 

1 (Ref)

0.61 (0.52 ~ 0.71)

0.48 (0.38 ~ 0.6)

0.44 (0.34 ~ 0.58)

 
  

 < 0.001

 < 0.001

 < 0.001

 

 Men

     
 

1 (Ref)

0.57 (0.5 ~ 0.65)

0.4 (0.34 ~ 0.46)

0.34 (0.29 ~ 0.4)

 
  

 < 0.001

 < 0.001

 < 0.001

 

Age

    

 < 0.001

 < 40

     
 

1 (Ref)

0.48 (0.38 ~ 0.6)

0.22 (0.16 ~ 0.31)

0.09 (0.06 ~ 0.13)

 
  

 < 0.001

 < 0.001

 < 0.001

 

 ≥ 40, < 60

     
 

1 (Ref)

0.73 (0.6 ~ 0.89)

0.43 (0.36 ~ 0.52)

0.33 (0.27 ~ 0.41)

 
  

0.002

 < 0.001

 < 0.001

 

 ≥ 60

     
 

1 (Ref)

0.84 (0.68 ~ 1.03)

0.63 (0.5 ~ 0.78)

0.7 (0.57 ~ 0.87)

 
  

0.089

0.655

0.001

 

BUN

    

0.009

 ≤ 7.1

     
 

1 (Ref)

0.6 (0.54 ~ 0.66)

0.43 (0.38 ~ 0.49)

0.34 (0.3 ~ 0.4)

 
  

 < 0.001

 < 0.001

 < 0.001

 

 > 7.1

     
 

1 (Ref)

0.33 (0.19 ~ 0.56)

0.21 (0.12 ~ 0.38)

0.54 (0.35 ~ 0.83)

 
  

0.309

0.035

0.005

 

Smoking status

    

0.048

 Current

     
 

1 (Ref)

0.37 (0.26 ~ 0.53)

0.2 (0.13 ~ 0.32)

0.18 (0.1 ~ 0.3)

 
  

 < 0.001

 < 0.001

 < 0.001

 

 Ever

     
 

1(Ref)

0.52 (0.2 ~ 1.35)

0.27 (0.08 ~ 0.87)

0.11 (0.03 ~ 0.42)

 
  

0.181

0.029

0.002

 

 Never

     
 

1(Ref)

0.5 (0.39 ~ 0.64)

0.38 (0.28 ~ 0.52)

0.37 (0.26 ~ 0.53)

 
  

 < 0.001

 < 0.001

 < 0.001

 

 No recorded

     
 

1 (Ref)

0.81 (0.71 ~ 0.91)

0.69 (0.61 ~ 0.79)

0.4 (0.34 ~ 0.47)

 
  

 < 0.001

 < 0.001

 < 0.001

 

Drinking status

    

0.049

 Current

     
 

1 (Ref)

0.30 (0.10 ~ 0.92)

0.27 (0.07 ~ 1.1)

0.11 (0.02 ~ 0.67)

 
  

0.035

0.068

0.017

 

 Ever

     
 

1 (Ref)

0.34 (0.21 ~ 0.55)

0.20 (0.10 ~ 0.38)

0.21 (0.09 ~ 0.46)

 
  

 < 0.001

 < 0.001

 < 0.001

 

 Never

     
 

1 (Ref)

0.50 (0.40 ~ 0.62)

0.34 (0.26 ~ 0.45)

0.3 (0.22 ~ 0.41)

 
  

 < 0.001

 < 0.001

 < 0.001

 

 No recorded

     
 

1(Ref)

0.63 (0.57 ~ 0.71)

0.46 (0.4 ~ 0.53)

0.4 (0.34 ~ 0.47)

 
  

 < 0.001

 < 0.001

 < 0.001

 

Family history of diabetes

    

0.997

 No

     
 

1(Ref)

0.59 (0.53 ~ 0.66)

0.42 (0.37 ~ 0.48)

0.36 (0.31 ~ 0.42)

 
  

 < 0.001

 < 0.001

 < 0.001

 

 Yes

     
 

1(Ref)

0.54 (0.34 ~ 0.85)

0.37 (0.19 ~ 0.7)

0.27 (0.12 ~ 0.59)

 
  

0.008

0.002

0.001

 
  1. Cre/BW creatinine to body weight, BUN blood urea nitrogen, T2DM type 2 diabetes mellitus, CI confidence interval, HR hazard ratio