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Fig. 6 | Diabetology & Metabolic Syndrome

Fig. 6

From: Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

Fig. 6

LSD1 induces renal fibrosis via decreasing SIRT3 expression and activating TGF-β1/Smad3 pathway. A The expression of α-SMA expression was assessed by IF assay (bar = 50 μm). B The expression of renal fibrosis biomarkers containing α-SMA, Fibronectin, collagen I and collagen IV were determined by western blot in NRK-49F cells. Each experiment repeated three times. **p < 0.01 vs. TGF-β1. ##p < 0.01 vs. TGF-β1 + Ad-LSD1

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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