Skip to main content
Fig. 3 | Diabetology & Metabolic Syndrome

Fig. 3

From: Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

Fig. 3

Knockdown of LSD1 alleviates renal fibrosis in STZ-induced DN rats. A Masson staining for renal fibrosis in different treated rats, suggesting that shLSD1 rescued STZ-induced renal fibrosis rats. The expression of Fibronectin (B) and α-SMA (C) were determined by IF assay, indicating shLSD1 reversed STZ-induced Fibronectin and α-SMA expression (bar = 100 μm). D The expression of α-SMA, collagen I and collagen IV were determined by western blot. Each group contained 10 rats. **p < 0.01 vs. Sham. ##p < 0.01 vs. STZ + Ad-shLSD1

Back to article page

Diabetology & Metabolic Syndrome

ISSN: 1758-5996

Contact us