Fig. 3
From: MiR-423-5p activated by E2F1 promotes neovascularization in diabetic retinopathy by targeting HIPK2
E2F1 facilitated miR-423-5p transcription. A Transfection of oe-E2F1 upregulated E2F1 mRNA and miR-423-5p levels while sh-E2F1 decreased both levels. B Transfection of oe-E2F1 increased the luciferase activity of miR-423-5p-WT but did not change the activity of miR-423-5p-MUT. All results were presented as the mean ± SD (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001. E2F1, E2F transcription factor 1; WT, wild-type; MUT, mutant; oe, overexpression