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Table 2 Summary ORs (95% CI) of VDR gene polymorphisms and gestational diabetes mellitus risk

From: The role of vitamin D receptor gene polymorphisms in gestational diabetes mellitus susceptibility: a meta-analysis

Site

Genetic model

Subgroup

Number

OR (95% CI)

P

P (Q test)

Egger

Begg

BsmI (rs1544410)

G vs A

Total

5

1.024 (0.512–2.048)

0.947

 < 0.001

0.399

0.806

Asian

2

1.959 (1.272–3.017)

0.002

0.549

  

African

1

0.301 (0.213–0.427)

 < 0.001

1.000

  

Caucasian

2

1.037 (0.742–1.450)

0.832

0.174

  

GG vs AA

Total

3

0.523 (0.109–2.504)

0.417

 < 0.001

0.616

1.000

African

1

0.109 (0.051–0.232)

 < 0.001

1.000

  

Caucasian

2

1.206 (0.749–1.941)

0.440

0.512

  

GA vs AA

Total

5

0.958 (0.414–2.214)

0.920

 < 0.001

0.529

1.000

Asian

2

2.059 (1.317–3.217)

0.002

0.472

  

African

1

0.234 (0.137–0.401)

 < 0.001

1.000

  

Caucasian

2

0.885 (0.409–1.915)

0.757

0.045

  

GA + GG vs AA

Total

5

0.937 (0.378–2.323)

0.888

 < 0.001

0.503

0.806

Asian

2

2.059 (1.317–3.217)

0.002

0.472

  

African

1

0.188 (0.113–0.312)

 < 0.001

1.000

  

Caucasian

2

0.940 (0.472–1.874)

0.861

0.053

  

GG vs AA + GA

Total

3

0.727 (0.261–2.025)

0.542

0.001

  

African

1

0.251 (0.126–0.498)

 < 0.001

1.000

  

Caucasian

2

1.208 (0.789–1.852)

0.385

0.842

  

GA vs AA + GG

Total

5

1.075 (0.612–1.891)

0.800

 < 0.001

0.358

0.462

Asian

2

2.059 (1.317–3.217)

0.002

0.472

  

African

1

0.526 (0.329–0.840)

0.007

1.000

  

Caucasian

2

0.840 (0.444–1.589)

0.592

0.068

  

FokI (rs2228570)

T vs C

Total

3

1.333 (0.852–2.085)

0.209

0.008

0.276

0.296

African

1

0.890 (0.643–1.231)

0.481

1.000

  

Caucasian

2

1.631 (1.142–2.329)

0.007

0.172

  

TT vs CC

Total

3

1.612 (0.672–3.865)

0.285

0.012

0.597

1.000

African

1

0.719 (0.368–1.405)

0.335

1.000

  

Caucasian

2

2.385 (1.079–5.272)

0.032

0.143

  

CT vs CC

Total

3

1.069 (0.593–1.929)

0.823

0.039

0.637

1.000

African

1

0.619 (0.334–1.146)

0.127

1.000

  

Caucasian

2

1.372 (0.799–2.355)

0.252

0.159

  

CT + TT vs CC

Total

3

1.229 (0.659–2.293)

0.516

0.013

  

African

1

0.654 (0.365–1.173)

0.154

1.000

  

Caucasian

2

1.624 (0.992–2.661)

0.054

0.154

  

TT vs CC + CT

Total

3

1.454 (1.037–2.040)

0.030

0.096

0.281

0.296

African

1

1.026 (0.625–1.686)

0.919

1.000

  

Caucasian

2

1.988 (1.235–3.200)

0.005

0.282

  

CT vs TT + CC

Total

3

0.964 (0.726–1.281)

0.803

0.191

0.03

0.296

African

1

0.760 (0.482–1.200)

0.240

1.000

  

Caucasian

2

1.121 (0.780–1.611)

0.538

0.204

  

Apal (rs7975232)

C vs A

Total

3

1.205 (0.998–1.456)

0.053

0.428

0.325

0.296

Asian

1

1.309 (0.949–1.807)

0.101

1.000

  

Caucasian

2

1.154 (0.914–1.458)

0.228

0.252

  

CC vs AA

Total

3

1.974 (1.276–3.054)

0.002

0.479

0.816

1.000

Asian

1

2.996 (1.278–7.022)

0.012

1.000

  

Caucasian

2

1.679 (1.006–2.804)

0.048

0.681

  

CA vs AA

Total

3

1.040 (0.760–1.422)

0.808

0.842

0.326

0.296

Asian

1

0.939 (0.579–1.523)

0.800

1.000

  

Caucasian

2

1.119 (0.741–1.688)

0.593

0.820

  

CA + CC vs AA

Total

3

1.267 (0.940–1.708)

0.121

0.747

0.359

0.296

Asian

1

1.121 (0.702–1.790)

0.633

1.000

  

Caucasian

2

1.378 (0.934–2.033)

0.106

0.704

  

CC vs AA + CA

Total

3

1.548 (1.080–2.217)

0.017

0.059

0.268

0.296

Asian

1

3.114 (1.403–6.912)

0.005

1.000

  

Caucasian

2

1.258 (0.835–1.895)

0.272

0.189

  

CA vs AA + CC

Total

3

0.828 (0.632–1.085)

0.172

0.748

0.331

0.296

Asian

1

0.733 (0.469–1.146)

0.174

1.000

  

Caucasian

2

0.889 (0.633–1.249)

0.497

0.719

  

TaqI (rs731236)

C vs T

Total

4

0.985 (0.758–1.279)

0.907

0.099

0.519

0.734

Asian

2

0.846 (0.582–1.231)

0.382

0.149

  

Caucasian

2

1.153 (0.896–1.484)

0.268

0.324

  

CC vs TT

Total

4

0.969 (0.681–1.379)

0.862

0.186

0.945

0.734

Asian

2

0.605 (0.345–1.060)

0.079

0.740

  

Caucasian

2

1.356 (0.851–2.161)

0.200

0.780

  

CT vs TT

Total

4

1.000 (0.541–1.848)

0.999

0.002

0.465

1.000

Asian

2

1.087 (0.252–4.677)

0.911

 < 0.001

  

Caucasian

2

0.940 (0.633–1.394)

0.757

0.353

  

CT + CC vs TT

Total

4

0.949 (0.619–1.454)

0.810

0.022

0.199

0.734

Asian

2

0.860 (0.351–2.112)

0.743

0.006

  

Caucasian

2

1.069 (0.731–1.563)

0.729

0.269

  

CC vs TT + CT

Total

4

1.049 (0.749–1.470)

0.781

0.225

0.963

1.000

Asian

2

0.713 (0.417–1.219)

0.216

0.286

  

Caucasian

2

1.374 (0.882–2.139)

0.160

0.963

  

CT vs TT + CC

Total

4

0.984 (0.552–1.753)

0.956

0.002

0.575

1.000

Asian

2

1.145 (0.281–4.663)

0.851

 < 0.001

  

Caucasian

2

0.869 (0.599–1.263)

0.463

0.411

  
  1. OR, odds ratio; CI, confidence interval; vs, versus; P (Q test), P value of Q test for heterogeneity test; Bolded terms reflected P < 0.05
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Diabetology & Metabolic Syndrome

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