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Table 2 Summary ORs (95% CI) of VDR gene polymorphisms and gestational diabetes mellitus risk

From: The role of vitamin D receptor gene polymorphisms in gestational diabetes mellitus susceptibility: a meta-analysis

Site Genetic model Subgroup Number OR (95% CI) P P (Q test) Egger Begg
BsmI (rs1544410) G vs A Total 5 1.024 (0.512–2.048) 0.947  < 0.001 0.399 0.806
Asian 2 1.959 (1.272–3.017) 0.002 0.549   
African 1 0.301 (0.213–0.427)  < 0.001 1.000   
Caucasian 2 1.037 (0.742–1.450) 0.832 0.174   
GG vs AA Total 3 0.523 (0.109–2.504) 0.417  < 0.001 0.616 1.000
African 1 0.109 (0.051–0.232)  < 0.001 1.000   
Caucasian 2 1.206 (0.749–1.941) 0.440 0.512   
GA vs AA Total 5 0.958 (0.414–2.214) 0.920  < 0.001 0.529 1.000
Asian 2 2.059 (1.317–3.217) 0.002 0.472   
African 1 0.234 (0.137–0.401)  < 0.001 1.000   
Caucasian 2 0.885 (0.409–1.915) 0.757 0.045   
GA + GG vs AA Total 5 0.937 (0.378–2.323) 0.888  < 0.001 0.503 0.806
Asian 2 2.059 (1.317–3.217) 0.002 0.472   
African 1 0.188 (0.113–0.312)  < 0.001 1.000   
Caucasian 2 0.940 (0.472–1.874) 0.861 0.053   
GG vs AA + GA Total 3 0.727 (0.261–2.025) 0.542 0.001   
African 1 0.251 (0.126–0.498)  < 0.001 1.000   
Caucasian 2 1.208 (0.789–1.852) 0.385 0.842   
GA vs AA + GG Total 5 1.075 (0.612–1.891) 0.800  < 0.001 0.358 0.462
Asian 2 2.059 (1.317–3.217) 0.002 0.472   
African 1 0.526 (0.329–0.840) 0.007 1.000   
Caucasian 2 0.840 (0.444–1.589) 0.592 0.068   
FokI (rs2228570) T vs C Total 3 1.333 (0.852–2.085) 0.209 0.008 0.276 0.296
African 1 0.890 (0.643–1.231) 0.481 1.000   
Caucasian 2 1.631 (1.142–2.329) 0.007 0.172   
TT vs CC Total 3 1.612 (0.672–3.865) 0.285 0.012 0.597 1.000
African 1 0.719 (0.368–1.405) 0.335 1.000   
Caucasian 2 2.385 (1.079–5.272) 0.032 0.143   
CT vs CC Total 3 1.069 (0.593–1.929) 0.823 0.039 0.637 1.000
African 1 0.619 (0.334–1.146) 0.127 1.000   
Caucasian 2 1.372 (0.799–2.355) 0.252 0.159   
CT + TT vs CC Total 3 1.229 (0.659–2.293) 0.516 0.013   
African 1 0.654 (0.365–1.173) 0.154 1.000   
Caucasian 2 1.624 (0.992–2.661) 0.054 0.154   
TT vs CC + CT Total 3 1.454 (1.037–2.040) 0.030 0.096 0.281 0.296
African 1 1.026 (0.625–1.686) 0.919 1.000   
Caucasian 2 1.988 (1.235–3.200) 0.005 0.282   
CT vs TT + CC Total 3 0.964 (0.726–1.281) 0.803 0.191 0.03 0.296
African 1 0.760 (0.482–1.200) 0.240 1.000   
Caucasian 2 1.121 (0.780–1.611) 0.538 0.204   
Apal (rs7975232) C vs A Total 3 1.205 (0.998–1.456) 0.053 0.428 0.325 0.296
Asian 1 1.309 (0.949–1.807) 0.101 1.000   
Caucasian 2 1.154 (0.914–1.458) 0.228 0.252   
CC vs AA Total 3 1.974 (1.276–3.054) 0.002 0.479 0.816 1.000
Asian 1 2.996 (1.278–7.022) 0.012 1.000   
Caucasian 2 1.679 (1.006–2.804) 0.048 0.681   
CA vs AA Total 3 1.040 (0.760–1.422) 0.808 0.842 0.326 0.296
Asian 1 0.939 (0.579–1.523) 0.800 1.000   
Caucasian 2 1.119 (0.741–1.688) 0.593 0.820   
CA + CC vs AA Total 3 1.267 (0.940–1.708) 0.121 0.747 0.359 0.296
Asian 1 1.121 (0.702–1.790) 0.633 1.000   
Caucasian 2 1.378 (0.934–2.033) 0.106 0.704   
CC vs AA + CA Total 3 1.548 (1.080–2.217) 0.017 0.059 0.268 0.296
Asian 1 3.114 (1.403–6.912) 0.005 1.000   
Caucasian 2 1.258 (0.835–1.895) 0.272 0.189   
CA vs AA + CC Total 3 0.828 (0.632–1.085) 0.172 0.748 0.331 0.296
Asian 1 0.733 (0.469–1.146) 0.174 1.000   
Caucasian 2 0.889 (0.633–1.249) 0.497 0.719   
TaqI (rs731236) C vs T Total 4 0.985 (0.758–1.279) 0.907 0.099 0.519 0.734
Asian 2 0.846 (0.582–1.231) 0.382 0.149   
Caucasian 2 1.153 (0.896–1.484) 0.268 0.324   
CC vs TT Total 4 0.969 (0.681–1.379) 0.862 0.186 0.945 0.734
Asian 2 0.605 (0.345–1.060) 0.079 0.740   
Caucasian 2 1.356 (0.851–2.161) 0.200 0.780   
CT vs TT Total 4 1.000 (0.541–1.848) 0.999 0.002 0.465 1.000
Asian 2 1.087 (0.252–4.677) 0.911  < 0.001   
Caucasian 2 0.940 (0.633–1.394) 0.757 0.353   
CT + CC vs TT Total 4 0.949 (0.619–1.454) 0.810 0.022 0.199 0.734
Asian 2 0.860 (0.351–2.112) 0.743 0.006   
Caucasian 2 1.069 (0.731–1.563) 0.729 0.269   
CC vs TT + CT Total 4 1.049 (0.749–1.470) 0.781 0.225 0.963 1.000
Asian 2 0.713 (0.417–1.219) 0.216 0.286   
Caucasian 2 1.374 (0.882–2.139) 0.160 0.963   
CT vs TT + CC Total 4 0.984 (0.552–1.753) 0.956 0.002 0.575 1.000
Asian 2 1.145 (0.281–4.663) 0.851  < 0.001   
Caucasian 2 0.869 (0.599–1.263) 0.463 0.411   
  1. OR, odds ratio; CI, confidence interval; vs, versus; P (Q test), P value of Q test for heterogeneity test; Bolded terms reflected P < 0.05