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Table 2 Association of the FT3 quartiles with DPN in type 2 diabetics

From: Serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes

  ORs (95% CI) p value for trend
Q4 Q3 Q2 Q1
Model 1 1 (ref.) 1.648 (1.101–2.468) 1.867 (1.238–2.814) 2.315 (1.530–3.503) 0.001
Model 2 1 (ref.) 1.746 (1.152–2.646) 1.985 (1.300–3.031) 2.445 (1.589–3.763) 0.001
Model 3 1 (ref.) 1.598 (0.960–1.125) 1.903 (1.134–3.194) 2.338 (1.407–3.884) 0.010
  1. Model 1: age, sex, smoking, alcohol and hypertension
  2. Model 2: Model 1 + DD, BMI, WHR, SBP and DBP
  3. Model 3: Model 2 + HbA1c, ALT, eGFR, SUA, UACR, TTC, TG, HDL-C, LDL-C, FPG, 2 h PPG, FCP, 2 h PCP, HOMA-IR, CRP, FT4 and TSH
  4. Q1 (quartile 1, FT3 3.10–4.10 pmol/L), Q2 (quartile 2, FT3 4.10–4.40 pmol/L), Q3 (quartile 3, FT3 4.40–4.72 pmol/L), Q4 (quartile 4, FT3 4.72–6.80 pmol/L), OR odds ratio, CI confidence interval, DD duration of diabetes, BMI body mass index, WHR waist hip ratio, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1c glycosylated haemoglobin A1c, ALT alanine aminotransferase, eGFR estimated glomerular filtration rate, SUA serum uric acid, UACR urine albumin-to-creatinine ratio, TTG total triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, FPG fasting plasma glucose, 2 h PPG 2 h postprandial plasma glucose, FCP fasting C-peptide, 2 h PCP 2-h postprandial C-peptide, HOMA-IR homeostatic model assessment of insulin resistance, CRP C-reactive protein, FT4 free thyroxine, TSH thyroid stimulating hormone