Variables | Q1 (n = 612) | Q2 (n = 616) | Q3 (n = 622) | Q4 (n = 627) | p value |
---|---|---|---|---|---|
FT3 (pmol/L) | 3.10–4.10 | 4.10–4.40 | 4.40–4.72 | 4.72–6.80 | – |
Age (years) | 64 ± 11 | 61 ± 11 | 58 ± 12 | 55 ± 11 |  < 0.001 |
Men (n, %) | 261 (42.6%) | 298 (48.4%) | 372 (59.8%) | 459 (73.2%) |  < 0.001 |
DD (months)a | 120 (48–180) | 96 (48–156) | 90 (36–144) | 72 (24–120) |  < 0.001 |
Smoking (n, %) | 114 (18.6%) | 133 (21.6%) | 160 (25.7%) | 241 (38.4%) |  < 0.001 |
Alcohol (n, %) | 48 (7.8%) | 71 (11.5%) | 85 (13.7%) | 114 (18.2%) | 0.002 |
Hypertension (n, %) | 314 (51.3%) | 330 (53.6%) | 300 (48.2%) | 270 (43.1%) | 0.001 |
BMI (kg/m2) | 24.63 ± 3.68 | 25.28 ± 3.38 | 25.08 ± 3.45 | 25.41 ± 3.38 | 0.001 |
WHR | 0.93 ± 0.35 | 0.92 ± 0.07 | 0.91 ± 0.06 | 0.92 ± 0.06 | 0.378 |
SBP (mmHg) | 133 ± 18 | 132 ± 17 | 132 ± 18 | 131 ± 16 | 0.016 |
DBP (mmHg) | 79 ± 10 | 79 ± 10 | 80 ± 9 | 82 ± 9 |  < 0.001 |
FPG (mmol/l)a | 7.55 (6.04–9.82) | 7.82 (6.31–10.08) | 7.90 (6.26–9.69) | 7.81 (6.40–9.63) | 0.481 |
2 h PPG (mmol/l) | 14.13 ± 4.96 | 14.07 ± 4.66 | 13.89 ± 4.66 | 13.67 ± 4.72 | 0.070 |
HbA1c (%)a | 9.3 (7.5–11.5) | 8.7 (7.3–10.5) | 8.5 (7.3–10.2) | 8.4 (7–9.9) |  < 0.001 |
FCP (ng/mL)a | 1.57 (0.89–2.40) | 1.73 (1.10–2.54) | 1.82 (1.20–2.53) | 1.89 (1.30–2.53) | 0.020 |
2 h PCP (ng/mL) | 3.75 ± 2.87 | 4.15 ± 2.74 | 4.46 ± 3.01 | 4.75 ± 2.71 |  < 0.001 |
HOMA-IRa | 4.94 (2.98–8.40) | 4.88 (2.96–7.85) | 4.59 (2.91–7.75) | 4.40 (2.72–7.40) | 0.292 |
TTG (mmol/L)a | 1.38 (0.92–2.08) | 1.50 (1.01–2.18) | 1.54 (1.04–2.41) | 1.51 (1.09–2.10) | 0.838 |
TC (mmol/L) | 4.88 ± 1.35 | 4.84 ± 1.33 | 4.79 ± 1.04 | 4.67 ± 0.99 | 0.001 |
HDL-C (mmol/L) | 1.17 ± 0.40 | 1.14 ± 0.31 | 1.10 ± 0.31 | 1.10 ± 0.28 |  < 0.001 |
LDL-C (mmol/L) | 3.16 ± 1.03 | 3.18 ± 0.98 | 3.24 ± 0.93 | 3.17 ± 0.92 | 0.512 |
ALT (U/l)a | 17 (12–26) | 19 (13–29) | 20 (14–30) | 20 (14–30) | 0.017 |
Scr (μmol/l)a | 63 (52–80) | 65 (55–77) | 65 (55–78) | 67 (56–78) | 0.014 |
SUA (μmol/l)a | 310 (251–369) | 300 (248–364) | 310 (265–377) | 319 (267–377) | 0.023 |
UACR (mg/g)a | 13.05 (6.56–40.28) | 11.73 (6.77–32.96) | 11.25 (6.51–27.99) | 10.14 (5.99–24.68) | 0.024 |
eGFR (ml/min/1.73 m2)a | 95.35 (76.97–118.23) | 101.37 (83.68–117.81) | 102.78 (86.18–120.92) | 108.25 (92.07–126.77) |  < 0.001 |
CRP (mg/L)a | 1.46 (0.53–3.87) | 1.09 (0.54–2.61) | 0.96 (0.47–2.12) | 0.93 (0.45–1.87) |  < 0.001 |
FT4 (pmol/L) | 15.96 ± 2.19 | 16.01 ± 2.20 | 16.34 ± 2.19 | 16.74 ± 2.21 |  < 0.001 |
TSH (mIU/L) | 1.74 ± 0.89 | 1.74 ± 0.81 | 1.69 ± 0.84 | 1.67 ± 0.85 | 0.405 |