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Table 1 Clinical characteristics of the subjects

From: Serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes

Variables Q1 (n = 612) Q2 (n = 616) Q3 (n = 622) Q4 (n = 627) p value
FT3 (pmol/L) 3.10–4.10 4.10–4.40 4.40–4.72 4.72–6.80
Age (years) 64 ± 11 61 ± 11 58 ± 12 55 ± 11  < 0.001
Men (n, %) 261 (42.6%) 298 (48.4%) 372 (59.8%) 459 (73.2%)  < 0.001
DD (months)a 120 (48–180) 96 (48–156) 90 (36–144) 72 (24–120)  < 0.001
Smoking (n, %) 114 (18.6%) 133 (21.6%) 160 (25.7%) 241 (38.4%)  < 0.001
Alcohol (n, %) 48 (7.8%) 71 (11.5%) 85 (13.7%) 114 (18.2%) 0.002
Hypertension (n, %) 314 (51.3%) 330 (53.6%) 300 (48.2%) 270 (43.1%) 0.001
BMI (kg/m2) 24.63 ± 3.68 25.28 ± 3.38 25.08 ± 3.45 25.41 ± 3.38 0.001
WHR 0.93 ± 0.35 0.92 ± 0.07 0.91 ± 0.06 0.92 ± 0.06 0.378
SBP (mmHg) 133 ± 18 132 ± 17 132 ± 18 131 ± 16 0.016
DBP (mmHg) 79 ± 10 79 ± 10 80 ± 9 82 ± 9  < 0.001
FPG (mmol/l)a 7.55 (6.04–9.82) 7.82 (6.31–10.08) 7.90 (6.26–9.69) 7.81 (6.40–9.63) 0.481
2 h PPG (mmol/l) 14.13 ± 4.96 14.07 ± 4.66 13.89 ± 4.66 13.67 ± 4.72 0.070
HbA1c (%)a 9.3 (7.5–11.5) 8.7 (7.3–10.5) 8.5 (7.3–10.2) 8.4 (7–9.9)  < 0.001
FCP (ng/mL)a 1.57 (0.89–2.40) 1.73 (1.10–2.54) 1.82 (1.20–2.53) 1.89 (1.30–2.53) 0.020
2 h PCP (ng/mL) 3.75 ± 2.87 4.15 ± 2.74 4.46 ± 3.01 4.75 ± 2.71  < 0.001
HOMA-IRa 4.94 (2.98–8.40) 4.88 (2.96–7.85) 4.59 (2.91–7.75) 4.40 (2.72–7.40) 0.292
TTG (mmol/L)a 1.38 (0.92–2.08) 1.50 (1.01–2.18) 1.54 (1.04–2.41) 1.51 (1.09–2.10) 0.838
TC (mmol/L) 4.88 ± 1.35 4.84 ± 1.33 4.79 ± 1.04 4.67 ± 0.99 0.001
HDL-C (mmol/L) 1.17 ± 0.40 1.14 ± 0.31 1.10 ± 0.31 1.10 ± 0.28  < 0.001
LDL-C (mmol/L) 3.16 ± 1.03 3.18 ± 0.98 3.24 ± 0.93 3.17 ± 0.92 0.512
ALT (U/l)a 17 (12–26) 19 (13–29) 20 (14–30) 20 (14–30) 0.017
Scr (μmol/l)a 63 (52–80) 65 (55–77) 65 (55–78) 67 (56–78) 0.014
SUA (μmol/l)a 310 (251–369) 300 (248–364) 310 (265–377) 319 (267–377) 0.023
UACR (mg/g)a 13.05 (6.56–40.28) 11.73 (6.77–32.96) 11.25 (6.51–27.99) 10.14 (5.99–24.68) 0.024
eGFR (ml/min/1.73 m2)a 95.35 (76.97–118.23) 101.37 (83.68–117.81) 102.78 (86.18–120.92) 108.25 (92.07–126.77)  < 0.001
CRP (mg/L)a 1.46 (0.53–3.87) 1.09 (0.54–2.61) 0.96 (0.47–2.12) 0.93 (0.45–1.87)  < 0.001
FT4 (pmol/L) 15.96 ± 2.19 16.01 ± 2.20 16.34 ± 2.19 16.74 ± 2.21  < 0.001
TSH (mIU/L) 1.74 ± 0.89 1.74 ± 0.81 1.69 ± 0.84 1.67 ± 0.85 0.405
  1. Values are expressed as the mean ± standard deviation, median with interquartile range, or percentages
  2. FT3 free triiodothyronine, DD duration of diabetes, BMI body mass index, WHR waist hip ratio, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, 2 h PPG 2 h postprandial plasma glucose, HbA1c glycosylated haemoglobin A1c, FCP fasting C-peptide, 2 h PCP 2-h postprandial C-peptide, HOMA-IR homeostatic model assessment of insulin resistance, TTG total triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ALT alanine aminotransferase, Scr serum creatinine, SUA serum uric acid, UACR urine albumin-to-creatinine ratio, eGFR estimated glomerular filtration rate, CRP C-reactive protein, FT4 free thyroxine, TSH thyroid stimulating hormone
  3. aNon-normal distribution of continuous variables