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Fig. 3 | Diabetology & Metabolic Syndrome

Fig. 3

From: Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model

Fig. 3

Effects of leucine (Leu) on ischemia/reperfusion (I/R) injury and mitochondrial fusion in high-fat diet (HFD)-induced obese mice. a HFD-induced obese mice were subjected to I/R. No significant difference in infarct size between the control (Cont) group and the ischemic preconditioning (IPC) group was observed, whereas Leu treatment reduced the infarct size caused by I/R injury in HFD-induced obese mice. The protective effect of Leu was abrogated by rapamycin (Rap). *p < 0.05, vs. Cont. b mTOR protein expression was examined in wild-type, mTOR+/−, and HFD-induced obese mice. Leu treatment increased mTOR expression in wild-type and HFD-induced obese mice, but not in mTOR+/− mice. Leu, leucine; HFD, high-fat diet; mTOR, mammalian target of rapamycin; Rap, rapamycin; Cont, control; GAPDH, glyceraldehyde 3-phosphate dehydrogenase. c The changes in mitochondrial dynamics caused by Leu were determined using electron microscopy. Enhanced mitochondrial fusion was observed in the heart tissues of HFD-induced obese mice

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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