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Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition

Fig. 5

CircSMAD4 overexpression alleviated HG-induced SV40-MES13 cell inflammation, ECM deposition and cell apoptosis by impairing miR-377-3p expression. A–G SV40-MES13 cells treated with HG were transfected with circSMAD4 or circSMAD4 + miR-377-3p. A–D The releases of IFN-γ, MCP-1, IL-6 and TNF-α in medium were determined by ELISA. E The protein levels of fibronectin and collagen IV were measured by western blot. F Cell apoptosis was assessed by flow cytometry assay. G The protein levels of Bcl-2 and Bax were measured by western blot. *P < 0.05

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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