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Fig. 4 | Diabetology & Metabolic Syndrome

Fig. 4

From: CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition

Fig. 4

MiR-377-3p was a target of circSMAD4. A The binding relationship between circSMAD4 and miR-377-3p was predicted by starbase. B The efficiency of miR-377-3p overexpression or inhibition was checked by qPCR. C and D The binding relationship between circSMAD4 and miR-377-3p was verified by dual-luciferase reporter assay and pull-down assay. E The expression of miR-377-3p in SV40-MES13 cells was treated with HG, NG or mannitol was detected by qPCR. F MiR-377-3p expression in HG-treated SV40-MES13 cells with circSMAD4 absence was checked by qPCR. *P < 0.05

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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