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Table 2 Odds ratio (OR), standard error (SE), Wald z, p-values and 95% CI for the six proteins that in the PIVUS study were significantly associated with all five metabolic syndrome (MetS) components in PIVUS (false discovery rate at 5%) and with at least 4 of the 5 MetS components in the ULSAM study (at nominal p-values p < 0.05)

From: Proteins associated with incident metabolic syndrome in population-based cohorts

 

OR

SE

z

p-value

95% CI

Leptin

PIVUS

 Fasting glucose

1.34

.14

2.79

5.3e−03

1.09–1.66

 Blood pressure

1.86

.22

5.15

2.7e−07

1.47–2.37

 Triglycerides

1.51

.17

3.64

2.7e−04

1.21–1.89

 HDL−cholesterol

1.58

.18

4.01

6.1e−05

1.26–1.99

 Waist circumference

6.27

.90

12.72

4.7e−37

4.72–8.32

ULSAM

 Fasting glucose

1.74

.20

4.61

4.0e−06

1.37–2.20

 Blood pressure

1.09

.18

0.54

5.9e−01

.78–1.52

 Triglycerides

1.85

.21

5.24

1.6e−07

1.47–2.33

 HDL-cholesterol

1.36

.16

2.59

9.6e−03

1.07–1.73

 Waist circumference

5.50

1.09

8.56

1.1e−17

3.72–8.13

t-PA

PIVUS

 Fasting glucose

1.22

.10

2.32

2.0e−02

1.03–1.46

 Blood pressure

1.29

.11

2.79

5.3e−03

1.07–1.55

 Triglycerides

1.74

.17

5.51

3.7e−08

1.43–2.13

 HDL-cholesterol

1.46

.14

3.81

1.4e−04

1.20–1.77

 Waist circumference

1.86

.15

7.30

2.8e−13

1.57–2.20

ULSAM

 Fasting glucose

2.28

.28

6.68

2.4e−11

1.79–2.90

 Blood pressure

1.09

.15

0.65

5.2e−01

.83–1.43

 Triglycerides

2.43

.30

7.05

1.8e−12

1.90–3.11

 HDL-cholesterol

1.50

.17

3.52

4.4e−04

1.19–1.89

 Waist circumference

2.12

.27

5.83

5.5e−09

1.64–2.73

FABP4

PIVUS

 Fasting glucose

1.29

.12

2.78

5.5e−03

1.08–1.56

 Blood pressure

1.40

.15

3.20

1.4e−03

1.14–1.73

 Triglycerides

1.79

.18

5.61

2.0e−08

1.46–2.19

 HDL-cholesterol

1.65

.17

4.72

2.3e−06

1.34–2.03

 Waist circumference

3.02

.30

10.94

0.0001

2.47–3.68

ULSAM

 Fasting glucose

1.58

.16

4.42

9.7e−06

1.29–1.93

 Blood pressure

1.20

.17

1.29

2.0e−01

.90–1.59

 Triglycerides

1.94

.21

6.08

1.2e−09

1.57–2.41

 HDL-cholesterol

1.36

.14

2.89

3.9e−03

1.10–1.68

 Waist circumference

2.87

.39

7.79

6.5e−15

2.20–3.75

IL-1RA

PIVUS

 Fasting glucose

1.45

.11

4.66

3.1e−06

1.24–1.71

 Blood pressure

1.66

.18

4.54

5.5e−06

1.33–2.06

 Triglycerides

1.56

.13

5.31

1.1e−07

1.32–1.84

 HDL-cholesterol

1.85

.16

6.87

6.2e−12

1.55–2.21

 Waist circumference

2.48

.22

10.20

2.0e−24

2.08–2.95

ULSAM

 Fasting glucose

1.39

.13

3.45

5.5e−04

1.15–1.68

 Blood pressure

1.37

.20

2.09

3.7e−02

1.01–1.84

 Triglycerides

1.80

.18

5.73

1.0e−08

1.47–2.20

 HDL-cholesterol

1.52

.15

4.07

4.8e−05

1.24–1.87

 Waist circumference

1.71

.18

5.03

4.9e−07

1.39–2.12

HGF

PIVUS

 Fasting glucose

1.38

.11

3.87

1.1e−04

1.17–1.63

 Blood pressure

1.26

.12

2.33

2.0e−02

1.03–1.54

 Triglycerides

1.46

.12

4.32

1.6e−05

1.23–1.73

 HDL-cholesterol

1.81

.17

6.29

3.3e−10

1.50–2.18

 Waist circumference

1.93

.16

7.83

5.0e−15

1.64–2.28

ULSAM

 Fasting glucose

1.39

.13

3.34

8.3e−04

1.14–1.69

 Blood pressure

1.05

.14

0.37

7.1e−01

.79–1.38

 Triglycerides

1.46

.14

3.79

1.5e−04

1.20–1.78

 HDL-cholesterol

1.30

.13

2.50

1.3e−02

1.05–1.60

 Waist circumference

1.50

.16

3.81

1.4e−04

1.22–1.86

CTSD

PIVUS

 Fasting glucose

1.63

.14

5.60

2.1e−08

1.37–1.93

 Blood pressure

1.27

.12

2.49

1.3e−02

1.05–1.55

 Triglycerides

1.82

.16

6.49

8.3e−11

1.52–2.19

 HDL-cholesterol

1.73

.16

5.69

1.2e−08

1.43–2.09

 Waist circumference

1.73

.14

6.75

1.5e−11

1.47–2.03

ULSAM

 Fasting glucose

1.92

.21

5.92

3.3e−09

1.55–2.39

 Blood pressure

1.05

.14

0.37

7.1e−01

.80–1.38

 Triglycerides

1.70

.18

5.00

5.8e−07

1.38–2.09

 HDL-cholesterol

1.44

.16

3.29

1.0e−03

1.15–1.79

 Waist circumference

1.56

.17

3.98

7.0e−05

1.25–1.94

  1. OR, p-values, and 95% CI are given in both the PIVUS study and the ULSAM study for the different MetS criteria. t-PA: Tissue-type plasminogen activator; FABP4: Fatty acid-binding protein 4; IL-1RA: Interleukin-1 receptor antagonist protein; HGF: Hepatocyte growth factor; CTSD: Cathepsin D