Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis

Table 3 Investigation of association between SNP − 11377 (rs266729) and type 2 diabetes risk using subgroup analyses

Subgroup	Number of studies	OR (95% CI)	Z-value	P-value	Test of heterogeneity
Subgroup	Number of studies	OR (95% CI)	Z-value	P-value	I² (%)	P
CC genotype	26	0.76 (0.53, 1.09)	− 1.44	0.14	< 0.001	97.7
Ethnicity
Asian	14	0.96 (0.79, 1.16)	− 0.36	0.71	79.1	< 0.001
European	7	0.78 (0.49, 1.22)	− 1.08	0.27	95.2	< 0.001
American	3	0.25 (0.02, 2.9)	− 1.09	0.27	99.7	< 0.001
African	2	0.83 (0.51, 1.3)	− 0.76	0.44	77.6	0.03
Study design
Case–control	20	0.69 (0.44, 1.07)	− 1.62	0.10	98.2	< 0.001
Cohort	6	1.04 (0.82, 1.34)	0.38	0.70	72.9	0.002
Sex
Male	26	0.90 (0.65, 1.23)	0.64	0.52	96	< 0.001
Female	25	1.28 (0.88, 1.86)	1.29	0.19	97.6	< 0.001
CG genotype	26	0.93 (0.72, 1.20)	0.58	0.58	< 0.001	95.3
Ethnicity
Asian	14	1.05 (0.89, 1.25)	0.64	0.52	71.9	< 0.001
European	7	0.90 (0.66, 1.23)	− 0.62	0.53	89	< 0.001
American	3	0.44 (0.08, 2.24)	− 0.97	0.32	99	< 0.001
African	2	1.2 (0.94, 1.58)	1.51	0.13	34.6	0.21
Study design
Case–control	20	0.88 (0.64, 1.22)	− 0.72	0.47	96.3	< 0.001
Cohort	6	1.05 (0.93, 1.20)	0.37	0.37	0.00	0.44
Sex
Male	25	0.99 (0.82, 1.19)	− 0.07	0.94	75.3	< 0.001
Female	24	1.003 (0.81, 1.23)	0.03	0.97	75.8	< 0.001
GG genotype	26	1.008 (0.80, 1.26)	0.067	0.94	< 0.001	75.7
Ethnicity
Asian	14	1.10 (0.96, 1.27)	1.28	0.14	41.9	0.05
European	7	1.01 (0.75, 1.37)	0.09	0.92	53.6	0.04
American	3	0.50 (0.11, 2.22)	− 0.90	0.36	96.1	< 0.001
African	2	1.41 (0.99, 2.02)	− 0.33	0.05	70	0.06
Study design
Case–control	20	0.96 (0.73, 1.25)	− 0.28	0.77	80.1	< 0.001
Cohort	6	1.27 (0.98, 1.66)	1.8	0.07	0.00	0.50
Sex
Male	24	1.10 (0.91, 1.33)	1.05	0.29	0.00	0.50
Female	24	0.90 (0.75, 1.09)	− 1.05	0.45	0.00	0.51

ISSN: 1758-5996