Row | First author | Publication year | Supplement type | Initial mean weight (kg) | Mean weight change (kg) | Final mean weight (kg) | P-value |
---|---|---|---|---|---|---|---|
1 | Apovian [25] | 2013 | Placebo | 99.2 ± 15.9 | − 1.5 ± 0.5 | 97.7 ± 15 |  < 0.001 |
Naltrexone + bupropion | 100.3 ± 16.6 | − 7.9 ± 0.3 | 92.4 ± 11 | ||||
2 | Aronne [26] | 2010 | Placebo | 107 ± 22 | − 2.1 ± 0.9 | 104.9 ± 21 |  < 0.05 |
Pramlintide | 102 ± 19 | − 3.6 ± 0.7 | 98.4 ± 18.5 | ||||
3 | Davies [27] | 2015 | Placebo | 106.5 ± 21.3 | − 2.2 | 104.3 ± 20 |  < 0.001 |
Liraglutide 0.3 mg | 105.7 ± 21.9 | − 6.4 | 99.3 ± 18.9 | ||||
Liraglutide 1.8 mg | 105.8 ± 21 | − 5 | 100.8 ± 19 | ||||
4 | Fidler [28] | 2011 | Placebo | 100.8 ± 16.2 | − 2.9 ± 6.4 | 97.9 ± 15 |  < 0.001 |
Lorcaserin 10 mg BID | 100.3 ± 15.7 | − 5.8 ± 6.4 | 94.5 ± 12 | ||||
Lorcaserin 10 mg QD | 100.1 ± 16.7 | − 4.7 ± 6.4 | 95.4 ± 13.5 | ||||
5 | Gadde [29] | 2011 | Placebo | 103.3 ± 18.1 | − 1.4 | 101.9 ± 17.5 |  < 0.0001 |
Phentermine 7.5 mg + topiramate 46.0 mg | 102.6 ± 18.2 | − 8.1 | 94.5 ± 15.5 | ||||
Phentermine 15.0 mg + topiramate 92.0 mg | 103 ± 17.6 | − 10.2 | 92.8 ± 10.6 | ||||
6 | Greenway [30] | 2010 | Placebo | 99.5 ± 14.3 | − 1.9 ± 0.5 | 97.6 ± 14 |  < 0.0001 |
Naltrexone + bupropion 16.0 mg | 99.5 ± 14.8 | − 6.5 ± 0.5 | 93 ± 11.5 | ||||
Naltrexone + bupropion 32.0 mg | 99.7 ± 15.9 | − 8 ± 0.5 | 91.7 ± 12 | ||||
7 | le Roux [31] | 2017 | Placebo | 107.9 ± 21.8 | − 2 ± 7.3 | 105.9 ± 21 |  < 0.0001 |
Liraglutide | 107.5 ± 21.6 | − 6.5 ± 8.1 | 101 ± 18 | ||||
8 | Lu [32] | 2018 | Placebo | 91.5 ± 14.5 | − 3.6 | 87.9 ± 13 | 0.044 |
Lorcaserin | 92.6 ± 13.3 | − 5.8 | 86.8 ± 10 | ||||
9 | O’neil [33] | 2012 | Placebo | 101.6 ± 18.1 |  | 101.7 ± 18.3 |  |
Orlistat 120.0 mg BID | 104.7 ± 17.9 |  | 104.7 ± 17.9 |  | |||
Orlistat 120.0 mg QD | 105.9 ± 19.0 |  | 105.4 ± 19.2 |  | |||
10 | Pi-Sunyer [34] | 2015 | Placebo | 106.2 ± 21.7 | − 2.8 ± 6.5 | 103.4 ± 20 |  < 0.001 |
Liraglutide | 106.2 ± 21.2 | − 8.4 ± 7.3 | 97.8 ± 17 | ||||
11 | Smith [35] | 2010 | Placebo | 99.7 ± 0.4 | − 2.2 ± 0.1 | 97.5 ± 0.4 |  < 0.001 |
Lorcaserin | 100.4 ± 0.4 | − 5.8 ± 0.2 | 94.6 ± 0.4 |