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Table 1 Information of studies included in the analysis step. mean age, sex and supplement type

From: RETRACTED ARTICLE: The best drug supplement for obesity treatment: a systematic review and network meta-analysis

Row

First author

Publication year

Setting

Mean age

Total patients

Supplement type

Men/women

Intervention

Control

1

Apovian [25]

2013

America

44.3 ± 11.2

44.4 ± 11.4

1496

Placebo

76/419

Naltrexone + bupropion

155/846

2

Aronne [26]

2010

America

42 ± 11

42 ± 11

244

Placebo

13/87

Pramlintide

12/88

3

Davies [27]

2015

France, Germany, Israel, South Africa, Spain, Sweden, Turkey, United Kingdom

 

57.4 ± 9.8

864

Placebo

97/115

Liraglutide 0.3 mg

220/203

Liraglutide 1.8 mg

108/103

4

Fidler [28]

2011

America

BID: 43.8 ± 11.8

43.7 ± 11.8

4004

Placebo

353/1248

QD: 43.8 ± 11.7

Lorcaserin 10 mg BID

313/1289

Lorcaserin 10 mg QD

145/656

5

Gadde [29]

2011

America

(7.5 mg + 46 mg): 51.1 ± 10.43

51.2 ± 10.25

2487

Placebo

299/695

(15 mg + 92 mg): 51.0 ± 10.65

Phentermine 7.5 mg + topiramate 46.0 mg

149/349

Phentermine 15.0 mg + topiramate 92.0 mg

302/693

6

Greenway [30]

2010

America

16 mg: 44.4 ± 11.3

43.7 ± 11.1

1742

Placebo

85/496

32 mg: 44.4 ± 11.1

Naltrexone + bupropion 16.0 mg

88/490

Naltrexone + bupropion 32.0 mg

87/496

7

le Roux [31]

2017

America

47.5 ± 11.7

47.3 ± 11.8

2254

Placebo

176/573

Liraglutide

364/1141

8

Lu [32]

2018

China

34.7 ± 9.0

37.0 ± 10.0

171

Placebo

28/57

Lorcaserin

39/46

9

O’neil [33]

2012

America

BID: 53.9 ± 8.1

53.2 ± 8.3

508

Placebo

73/84

QD: 53.5 ± 7.4

Orlistat 120.0 mg BID

86/83

Orlistat 120.0 mg QD

34/41

10

Pi-Sunyer [34]

2015

Europe, North America, South America, Asia, Africa, Australia

45.0 ± 12.0

45.2 ± 12.1

3731

Placebo

273/971

Liraglutide

530/1957

11

Smith [35]

2010

America

43.8 ± 0.3

44.4 ± 0.3

3182

Placebo

253/1331

Lorcaserin

272/1321