Row | First author | Publication year | Setting | Mean age | Total patients | Supplement type | Men/women | |
---|---|---|---|---|---|---|---|---|
Intervention | Control | |||||||
1 | Apovian [25] | 2013 | America | 44.3 ± 11.2 | 44.4 ± 11.4 | 1496 | Placebo | 76/419 |
Naltrexone + bupropion | 155/846 | |||||||
2 | Aronne [26] | 2010 | America | 42 ± 11 | 42 ± 11 | 244 | Placebo | 13/87 |
Pramlintide | 12/88 | |||||||
3 | Davies [27] | 2015 | France, Germany, Israel, South Africa, Spain, Sweden, Turkey, United Kingdom |  | 57.4 ± 9.8 | 864 | Placebo | 97/115 |
Liraglutide 0.3Â mg | 220/203 | |||||||
Liraglutide 1.8Â mg | 108/103 | |||||||
4 | Fidler [28] | 2011 | America | BID: 43.8 ± 11.8 | 43.7 ± 11.8 | 4004 | Placebo | 353/1248 |
QD: 43.8 ± 11.7 | Lorcaserin 10 mg BID | 313/1289 | ||||||
Lorcaserin 10Â mg QD | 145/656 | |||||||
5 | Gadde [29] | 2011 | America | (7.5 mg + 46 mg): 51.1 ± 10.43 | 51.2 ± 10.25 | 2487 | Placebo | 299/695 |
(15 mg + 92 mg): 51.0 ± 10.65 | Phentermine 7.5 mg + topiramate 46.0 mg | 149/349 | ||||||
Phentermine 15.0 mg + topiramate 92.0 mg | 302/693 | |||||||
6 | Greenway [30] | 2010 | America | 16 mg: 44.4 ± 11.3 | 43.7 ± 11.1 | 1742 | Placebo | 85/496 |
32 mg: 44.4 ± 11.1 | Naltrexone + bupropion 16.0 mg | 88/490 | ||||||
Naltrexone + bupropion 32.0 mg | 87/496 | |||||||
7 | le Roux [31] | 2017 | America | 47.5 ± 11.7 | 47.3 ± 11.8 | 2254 | Placebo | 176/573 |
Liraglutide | 364/1141 | |||||||
8 | Lu [32] | 2018 | China | 34.7 ± 9.0 | 37.0 ± 10.0 | 171 | Placebo | 28/57 |
Lorcaserin | 39/46 | |||||||
9 | O’neil [33] | 2012 | America | BID: 53.9 ± 8.1 | 53.2 ± 8.3 | 508 | Placebo | 73/84 |
QD: 53.5 ± 7.4 | Orlistat 120.0 mg BID | 86/83 | ||||||
Orlistat 120.0Â mg QD | 34/41 | |||||||
10 | Pi-Sunyer [34] | 2015 | Europe, North America, South America, Asia, Africa, Australia | 45.0 ± 12.0 | 45.2 ± 12.1 | 3731 | Placebo | 273/971 |
Liraglutide | 530/1957 | |||||||
11 | Smith [35] | 2010 | America | 43.8 ± 0.3 | 44.4 ± 0.3 | 3182 | Placebo | 253/1331 |
Lorcaserin | 272/1321 |