| All patients | High MMP-14 (≥  5.81 ng/mL) | Cardiovascular disease | ||||
---|---|---|---|---|---|---|---|
268 | Yes | No | Pa | Yes | No | Pa | |
 |  | 67 | 201 |  | 7 | 261 |  |
MMP-14 (ng/mL) | (0.00–447.0) | 18.4 (10.2, 42.1) | 0.65 (0.0, 1.92) | <  0.001 | 12.2 (2.1, 95.3) | 1.5 (0.0, 5.4) | 0.020 |
MMP-14  ≥  5.81 (ng/mL) | 67 (25) | – | – | – | 5 (71) | 62 (24) | 0.012b |
MMP-2 (ng/mL) | (65.7–434.0) | 164.0 (135.0, 197) | 150 (128.5, 175.5) | 0.018 | 176.0 (162.8, 217.5) | 154.0 (129.8, 177.2) | 0.16 |
MMP-9 (ng/mL) | (222–1936) | 515 (400, 637) | 518 (408–720) | 0.58 | 518 (447–835) | 515 (405–702) | 0.55 |
TIMP-2 (ng/mL)c | (0.00–468.0) | 187.0 (161.0, 213.0) | 174.5 (151.0, 202.8) | 0.060 | 205.0 (195.0, 263.0) | 178.0 (152.5, 205.0) | 0.028 |
TIMP-3 (ng/mL)d | (1.2–692.3) | 8.2 (5.9, 11.0) | 8.4 (5.8, 12.0) | 0.71 | 9.2 (6.3, 13.1) | 8.2 (5.8, 11.4) | 0.40 |
Galectin-3 (ng/mL)e | (0.001–36.4) | 1.9 (1.0, 3.5) | 0.8 (0.5, 1.4) | <  0.001 | 1.7 (0.6–3.2) | 0.9 (0.6–1.7) | 0.44 |
CRP (mg/L)f | (0.03–8.4) | 0.6 (0.2, 1.9) | 0.7 (0.3, 1.7) | 0.72 | 0.6 (0.4, 5.0) | 0.6 (0.2–1.6) | 0.40 |
HbA1c | |||||||
 (mmol/mol) | (25–110) | 58 (53, 67) | 63 (54, 71) | 0.054 | 65 (51, 74) | 63 (54, 71) | 0.94 |
 (%) | (4.4–12.2) | 7.5 (7.0, 8.3) | 8.0 (7.1, 8.7) |  | 8.1 (6.8, 8.9) | 7.9 (7.1, 8.6) | |
Total cholesterol (mmol/L) | (2.1–10.9) | 4.7 (4.1, 5.2) | 4.5 (4.1, 5.1) | 0.53 | 4.0 (3.6, 5.0) | 4.6 (4.1, 5.1) | 0.12 |
LDL-cholesterol (mmol/L) | (0.6–8.3) | 3.0 (2.5, 3.4) | 2.7 (2.4, 3.3) | 0.16 | 2.1 (1.9, 3.2) | 2.8 (2.4, 3.3) | 0.063 |
HDL-cholesterol (mmol/L) | (0.3–2.7) | 1.4 (1.2, 1.8) | 1.3 (1.5, 1.8) | 0.44 | 1.7 (1.3, 2.0) | 1.5 (1.3, 1.8) | 0.44 |
Triglycerides (mmol/L) | (0.06–5.9) | 1.0 (0.7, 1.3) | 0.8 (0.7, 1.2) | 0.102 | 1.0 (0.6, 1.5) | 0.9 (0.7, 1.2) | 0.88 |
S-creatinine (mmol/L)g | (28–182) | 70 (64, 79) | 70 (62, 78) | 0.62 | 70 (64, 80) | 70 (62, 78) | 0.95 |