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Table 2 Biochemical analyses compared between people with high and low MMP-14 and between people with and without CVD

From: Galectin-3, metalloproteinase-2 and cardiovascular disease were independently associated with metalloproteinase-14 in patients with type 1 diabetes: a cross sectional study

 

All patients

High MMP-14 (≥  5.81 ng/mL)

Cardiovascular disease

268

Yes

No

Pa

Yes

No

Pa

  

67

201

 

7

261

 

MMP-14 (ng/mL)

(0.00–447.0)

18.4 (10.2, 42.1)

0.65 (0.0, 1.92)

<  0.001

12.2 (2.1, 95.3)

1.5 (0.0, 5.4)

0.020

MMP-14  ≥  5.81 (ng/mL)

67 (25)

–

–

–

5 (71)

62 (24)

0.012b

MMP-2 (ng/mL)

(65.7–434.0)

164.0 (135.0, 197)

150 (128.5, 175.5)

0.018

176.0 (162.8, 217.5)

154.0 (129.8, 177.2)

0.16

MMP-9 (ng/mL)

(222–1936)

515 (400, 637)

518 (408–720)

0.58

518 (447–835)

515 (405–702)

0.55

TIMP-2 (ng/mL)c

(0.00–468.0)

187.0 (161.0, 213.0)

174.5 (151.0, 202.8)

0.060

205.0 (195.0, 263.0)

178.0 (152.5, 205.0)

0.028

TIMP-3 (ng/mL)d

(1.2–692.3)

8.2 (5.9, 11.0)

8.4 (5.8, 12.0)

0.71

9.2 (6.3, 13.1)

8.2 (5.8, 11.4)

0.40

Galectin-3 (ng/mL)e

(0.001–36.4)

1.9 (1.0, 3.5)

0.8 (0.5, 1.4)

<  0.001

1.7 (0.6–3.2)

0.9 (0.6–1.7)

0.44

CRP (mg/L)f

(0.03–8.4)

0.6 (0.2, 1.9)

0.7 (0.3, 1.7)

0.72

0.6 (0.4, 5.0)

0.6 (0.2–1.6)

0.40

HbA1c

 (mmol/mol)

(25–110)

58 (53, 67)

63 (54, 71)

0.054

65 (51, 74)

63 (54, 71)

0.94

 (%)

(4.4–12.2)

7.5 (7.0, 8.3)

8.0 (7.1, 8.7)

 

8.1 (6.8, 8.9)

7.9 (7.1, 8.6)

Total cholesterol (mmol/L)

(2.1–10.9)

4.7 (4.1, 5.2)

4.5 (4.1, 5.1)

0.53

4.0 (3.6, 5.0)

4.6 (4.1, 5.1)

0.12

LDL-cholesterol (mmol/L)

(0.6–8.3)

3.0 (2.5, 3.4)

2.7 (2.4, 3.3)

0.16

2.1 (1.9, 3.2)

2.8 (2.4, 3.3)

0.063

HDL-cholesterol (mmol/L)

(0.3–2.7)

1.4 (1.2, 1.8)

1.3 (1.5, 1.8)

0.44

1.7 (1.3, 2.0)

1.5 (1.3, 1.8)

0.44

Triglycerides (mmol/L)

(0.06–5.9)

1.0 (0.7, 1.3)

0.8 (0.7, 1.2)

0.102

1.0 (0.6, 1.5)

0.9 (0.7, 1.2)

0.88

S-creatinine (mmol/L)g

(28–182)

70 (64, 79)

70 (62, 78)

0.62

70 (64, 80)

70 (62, 78)

0.95

  1. Data are presented as N (%), (min–max) or median (q1, q3)
  2. aMann–Whitney U test unless indicated
  3. bFisher’s Exact Test
  4. c1; d7; e4; f78; g11: missing variables