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Fig. 3 | Diabetology & Metabolic Syndrome

Fig. 3

From: CDKN2B-AS1 participates in high glucose-induced apoptosis and fibrosis via NOTCH2 through functioning as a miR-98-5p decoy in human podocytes and renal tubular cells

Fig. 3

CDKN2B-AS1 acted as a sponge for miR-98-5p. A The binding sites between CDKN2B-AS1 and miR-98-5p were predicted by the starBase database. B, C Dual-luciferase reporter assay was executed for the assessment of the luciferase reporter with WT-CDKN2B-AS1 or MUT-CDKN2B-AS1 in HPCs and HK-2 cells transfected with miR-98-5p mimic or miRNA NC. D The expression of miR-98-5p in HPCs and HK-2 cells transfected with miR-98-5p inhibitor or inhibitor NC was detected via qRT-PCR. E, F Impact of miR-98-5p inhibitor on the expression of miR-98-5p in CDKN2B-AS1-inhibiting HPCs and HK-2 cells was analyzed through qRT-PCR. G, H The expression of miR-98-5p in serum of DN patients and high glucose-treated HPCs and HK-2 cells was determined via qRT-PCR. *P < 0.05

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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