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Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: CDKN2B-AS1 participates in high glucose-induced apoptosis and fibrosis via NOTCH2 through functioning as a miR-98-5p decoy in human podocytes and renal tubular cells

Fig. 2

Effects of CDKN2B-AS1 on apoptosis and fibrosis of HPCs and HK-2 cells under high glucose treatment. A, B The expression of CDKN2B-AS1 in HPCs and HK-2 cells transfected with vector, CDKN2B-AS1, si-NC, or si-CDKN2B-AS1 under high glucose stimulation was analyzed with qRT-PCR. C–F Effects of CDKN2B-AS1 overexpression and inhibition on the proliferation and apoptosis of high glucose-disposed HPCs and HK-2 cells were determined through MTT or flow cytometry assays. G–J Effects of CDKN2B-AS1 overexpression and inhibition on protein levels of Bax, Bcl-2, TGF-β1, FN, and Col.I in high glucose-disposed HPCs and HK-2 cells were analyzed by western blot analysis.*P < 0.05

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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