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Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: Activation of mTOR mediates hyperglycemia-induced renal glomerular endothelial hyperpermeability via the RhoA/ROCK/pMLC signaling pathway

Fig. 2

Rapamycin reversed hyperpermeability in HG-cultured HRGECs. The TEER (a) and HRP-albumin permeability (Pa) of transendothelial flux (b) were measured in HRGECs treated with rapamycin (0, 50, 100, or 500 nM) for 2 h with or without HG (30 mM) stimulation for 22 h. TEER was normalized to the baseline before treatment (TEER0) (n = 3). HG, high glucose; HRGECs, human renal glomerular endothelial cells; TEER, transendothelial electric resistance; HRP, horseradish peroxidase. ** indicates p < 0.01; *** indicates p < 0.001

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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