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Table 2 Clinical characteristics of study GCK-MODY and HFN1A-MODY patients

From: Clinical and genetic features of maturity-onset diabetes of the young in pediatric patients: a 12-year monocentric experience

 

GCK-MODY

HNF1A-MODY

Number of patients

30 (81%)

5 (13.5%)

Age at diagnosis (yrs)

8.5 ± 4.5

9.9 ± 5.6

BMI at diagnosis

(Z-score)

 − 0.2 ± 1.1

0.6 ± 1.16

HbA1c at onset (%)

6.5 ± 0.5

7.3 ± 2.2

HbA1c at onset (mmol/mol)

48 ± 6

56 ± 24

OGTT: 0ˈ glucose (mmol/l)

6.26 ± 0.93

7.02 ± 0.98

OGTT: 120ˈ glucose (mmol/l)

9.22 ± 1.89

14.15 ± 4.83

C-peptide at onset (ng/dl)

0.8 ± 0.5

1.8 ± 1.0

Weight at birth (kg)

2.95 ± 0.6

2.90 ± 0.5

HLA

 DR3 and/or DR4

10 (33.3%)

1 (20%)

Autoantibodies

 ICA

1

0

 IA2

1

0

 GADA

2

0

Treatment

 Diet only

29

1

 Insulin

1

2

 OHA

0

2

  1. BMI Body Mass Index, GADA glutamic acid decarboxylase 65 autoantibodies, HbA1c glycated haemoglobin, HLA human leukocyte antigens, IA2 tyrosine phosphatase-like insulinoma antigen 2 autoantibodies, ICA islet cell autoantibodies, OGTT oral glucose tolerance test, OHA oral hypoglycemic agents