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Fig. 6 | Diabetology & Metabolic Syndrome

Fig. 6

From: Long non-coding RNA CASC2 restrains high glucose-induced proliferation, inflammation and fibrosis in human glomerular mesangial cells through mediating miR-135a-5p/TIMP3 axis and JNK signaling

Fig. 6

HG treatment increases the phosphorylation level of JNK partly through targeting CASC2/miR-135a-5p/TIMP3 axis. A, B The levels of JNK and p-JNK were detected in HMCs treated with NG, HG, HG + vector or HG + oe-lncRNA CASC2 by Western blot assay. C, D HMCs transfected with oe-lncRNA CASC2 alone or together with miR-135a-5p mimic or si-TIMP3 were stimulated by HG for 48 h. The levels of JNK and p-JNK were determined by Western blot assay. *P < 0.05

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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