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Table 4 HLA-DRB1*/HLA-DRB1* genotypes distribution in patients with severe DR and patients without DR

From: Human Leukocyte Antigens class II (HLA II) gene profile from an admixed population of patients with type 1 diabetes with severe diabetic retinopathy: a nested case-control study in Brazil

HLA-DRB1*/HLA-DRB1* Patients with severe DR N  =  117 Patients without DR N  =  117 OR (CI) p
N (%) N (%)
HLA-DRB1*03/HLA-DRB1*03 13 (11.11) 15 (12.82) 0.85 (0.38–1.87) 0.69
HLA-DRB1*03/HLA-DRB1*04 31 (26.50) 31 (26.50) 1.00 (0.56–1.79) 1.00
HLA-DRB1*03/X 10 (8.55) 16 (13.68) 0.59 (0.27–1.36) 0.21
HLA-DRB1*04/HLA-DRB1*04 6 (5.13) 5 (4.27) 1.21 (0.36–4.09) 0.76
HLA-DRB1*04/X 20 (17.09) 20 (17.09) 1.00 (0.51–1.97) 1.00
HLA-DRB1*09/HLA-DRB1*03 3 (2.56) 4 (3.42) 0.74 (0.16–3.40) 0.70
HLA-DRB1*09/HLA-DRB1*04 0 (0.00) 1 (0.85)    NA
HLA-DRB1*09/HLA-DRB1*09 0 (0.00) 0 (0.00)    NA
HLA-DRB1*09/X 1 (0.85) 5 (4.27) 0.19 (0.02–1.68) 0.10
HLA-DRB1*13/HLA-DRB1*13 0 (0.00) 0 (0.00)    NA
HLA-DRB1*13/HLA-DRB1*03 3 (2.56) 1 (0.85) 3.05 (0.31–29.78) 0.31
HLA-DRB1*13/HLA-DRB1*04 7 (5.98) 5 (4.27) 1.42 (0.44–4.63) 0.55
HLA-DRB1*13/X 10 (8.55) 2 (1.71) 5.37 (1.15–25.09) 0.02
DRX/DRX 13 (11.11) 12 (10.26) 1.09 (0.48–2.51) 0.83
  1. Bold represents statistical significance (p < 0.05) before Bonferroni correction
  2. p value required for significance after Bonferroni correction 0.004
  3. DR diabetic retinopathy; N number of individuals; OR odds ratio; CI confidence interval; NA non applicable; DRX any haplotype other than HLA-DRB1*03, HLA-DRB1*04, HLA-DRB1*09 or HLA-DRB1*13