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Table 4 HLA-DRB1*/HLA-DRB1* genotypes distribution in patients with severe DR and patients without DR

From: Human Leukocyte Antigens class II (HLA II) gene profile from an admixed population of patients with type 1 diabetes with severe diabetic retinopathy: a nested case-control study in Brazil

HLA-DRB1*/HLA-DRB1*

Patients with severe DR N  =  117

Patients without DR N  =  117

OR

(CI)

p

N

(%)

N

(%)

HLA-DRB1*03/HLA-DRB1*03

13

(11.11)

15

(12.82)

0.85

(0.38–1.87)

0.69

HLA-DRB1*03/HLA-DRB1*04

31

(26.50)

31

(26.50)

1.00

(0.56–1.79)

1.00

HLA-DRB1*03/X

10

(8.55)

16

(13.68)

0.59

(0.27–1.36)

0.21

HLA-DRB1*04/HLA-DRB1*04

6

(5.13)

5

(4.27)

1.21

(0.36–4.09)

0.76

HLA-DRB1*04/X

20

(17.09)

20

(17.09)

1.00

(0.51–1.97)

1.00

HLA-DRB1*09/HLA-DRB1*03

3

(2.56)

4

(3.42)

0.74

(0.16–3.40)

0.70

HLA-DRB1*09/HLA-DRB1*04

0

(0.00)

1

(0.85)

  

NA

HLA-DRB1*09/HLA-DRB1*09

0

(0.00)

0

(0.00)

  

NA

HLA-DRB1*09/X

1

(0.85)

5

(4.27)

0.19

(0.02–1.68)

0.10

HLA-DRB1*13/HLA-DRB1*13

0

(0.00)

0

(0.00)

  

NA

HLA-DRB1*13/HLA-DRB1*03

3

(2.56)

1

(0.85)

3.05

(0.31–29.78)

0.31

HLA-DRB1*13/HLA-DRB1*04

7

(5.98)

5

(4.27)

1.42

(0.44–4.63)

0.55

HLA-DRB1*13/X

10

(8.55)

2

(1.71)

5.37

(1.15–25.09)

0.02

DRX/DRX

13

(11.11)

12

(10.26)

1.09

(0.48–2.51)

0.83

  1. Bold represents statistical significance (p < 0.05) before Bonferroni correction
  2. p value required for significance after Bonferroni correction 0.004
  3. DR diabetic retinopathy; N number of individuals; OR odds ratio; CI confidence interval; NA non applicable; DRX any haplotype other than HLA-DRB1*03, HLA-DRB1*04, HLA-DRB1*09 or HLA-DRB1*13