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Table 3 Distribution of the HLA-DRB1 ~ DQA1 ~ DQB1 haplotypes in patients with severe DR and patients without DR

From: Human Leukocyte Antigens class II (HLA II) gene profile from an admixed population of patients with type 1 diabetes with severe diabetic retinopathy: a nested case-control study in Brazil

Haplotype Patients with severe DR N  =  117 Patients without DR N  =  117 OR (CI) p
HLA-DRB1 ~ DQA1 ~ DQB1 N % N %
03:01 ~ 05:01 g ~ 02:01 68 (29.06) 78 (33.33) 0.82 (0.55–1.21) 0.32
04:05 ~ 03:01 g ~ 03:02 33 (14.10) 20 (8.55) 1.75 (0.97–3.16) 0.06
07:01 ~ 02:01 ~ 02:02 16 (6.84) 21 (8.97) 0.74 (0.38–1.46) 0.39
04:02 ~ 03:01 g ~ 03:02 13 (5.56) 13 (5.56) 1.00 (0.45–2.21) 1
04:01 ~ 03:01 g ~ 03:02 5 (2.14) 13 (5.56) 0.37 (0.13–1.06) 0.05
04:04 ~ 03:01 g ~ 03:02 7 (2.99) 9 (3.85) 0.77 (0.28–2.11) 0.61
09:01 ~ 03:01 g ~ 02:02 4 (1.71) 8 (3.42) 0.49 (0.15–1.65) 0.24
13:02 ~ 01:02 ~ 06:04 10 (4.27) 2 (0.85) 5.18 (1.12–23.90) 0.02
01:01 ~ 01:01 g ~ 05:01 5 (2.14) 6 (2.56) 0.83 (0.25–2.76) 0.76
Others 73 (31.20) 64 (27.35) 1.2 (0.81–1.80) 0.36
  1. Bold represents statistical significance (p < 0.05)
  2. Rare alleles were included in others
  3. DR  diabetic retinopathy; N number of individuals; OR odds ratio; CI confidence interval