|
Haplotype
|
Patients with severe DR N = 117
|
Patients without DR N = 117
|
OR
|
(CI)
|
p
|
|---|
|
HLA-DRB1 ~ DQA1 ~ DQB1
|
N
|
%
|
N
|
%
|
|---|
|
03:01 ~ 05:01 g ~ 02:01
|
68
|
(29.06)
|
78
|
(33.33)
|
0.82
|
(0.55–1.21)
|
0.32
|
|
04:05 ~ 03:01 g ~ 03:02
|
33
|
(14.10)
|
20
|
(8.55)
|
1.75
|
(0.97–3.16)
|
0.06
|
|
07:01 ~ 02:01 ~ 02:02
|
16
|
(6.84)
|
21
|
(8.97)
|
0.74
|
(0.38–1.46)
|
0.39
|
|
04:02 ~ 03:01 g ~ 03:02
|
13
|
(5.56)
|
13
|
(5.56)
|
1.00
|
(0.45–2.21)
|
1
|
|
04:01 ~ 03:01 g ~ 03:02
|
5
|
(2.14)
|
13
|
(5.56)
|
0.37
|
(0.13–1.06)
|
0.05
|
|
04:04 ~ 03:01 g ~ 03:02
|
7
|
(2.99)
|
9
|
(3.85)
|
0.77
|
(0.28–2.11)
|
0.61
|
|
09:01 ~ 03:01 g ~ 02:02
|
4
|
(1.71)
|
8
|
(3.42)
|
0.49
|
(0.15–1.65)
|
0.24
|
|
13:02 ~ 01:02 ~ 06:04
|
10
|
(4.27)
|
2
|
(0.85)
|
5.18
|
(1.12–23.90)
|
0.02
|
|
01:01 ~ 01:01 g ~ 05:01
|
5
|
(2.14)
|
6
|
(2.56)
|
0.83
|
(0.25–2.76)
|
0.76
|
|
Others
|
73
|
(31.20)
|
64
|
(27.35)
|
1.2
|
(0.81–1.80)
|
0.36
|
- Bold represents statistical significance (p < 0.05)
- Rare alleles were included in others
- DR diabetic retinopathy; N number of individuals; OR odds ratio; CI confidence interval
