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Table 3 Distribution of the HLA-DRB1 ~ DQA1 ~ DQB1 haplotypes in patients with severe DR and patients without DR

From: Human Leukocyte Antigens class II (HLA II) gene profile from an admixed population of patients with type 1 diabetes with severe diabetic retinopathy: a nested case-control study in Brazil

Haplotype

Patients with severe DR N  =  117

Patients without DR N  =  117

OR

(CI)

p

HLA-DRB1 ~ DQA1 ~ DQB1

N

%

N

%

03:01 ~ 05:01 g ~ 02:01

68

(29.06)

78

(33.33)

0.82

(0.55–1.21)

0.32

04:05 ~ 03:01 g ~ 03:02

33

(14.10)

20

(8.55)

1.75

(0.97–3.16)

0.06

07:01 ~ 02:01 ~ 02:02

16

(6.84)

21

(8.97)

0.74

(0.38–1.46)

0.39

04:02 ~ 03:01 g ~ 03:02

13

(5.56)

13

(5.56)

1.00

(0.45–2.21)

1

04:01 ~ 03:01 g ~ 03:02

5

(2.14)

13

(5.56)

0.37

(0.13–1.06)

0.05

04:04 ~ 03:01 g ~ 03:02

7

(2.99)

9

(3.85)

0.77

(0.28–2.11)

0.61

09:01 ~ 03:01 g ~ 02:02

4

(1.71)

8

(3.42)

0.49

(0.15–1.65)

0.24

13:02 ~ 01:02 ~ 06:04

10

(4.27)

2

(0.85)

5.18

(1.12–23.90)

0.02

01:01 ~ 01:01 g ~ 05:01

5

(2.14)

6

(2.56)

0.83

(0.25–2.76)

0.76

Others

73

(31.20)

64

(27.35)

1.2

(0.81–1.80)

0.36

  1. Bold represents statistical significance (p < 0.05)
  2. Rare alleles were included in others
  3. DR  diabetic retinopathy; N number of individuals; OR odds ratio; CI confidence interval