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Table 2 HLA-DRB1*, -DQB1*, and -DQA1* alleles distribution in patients with severe DR and patients without DR

From: Human Leukocyte Antigens class II (HLA II) gene profile from an admixed population of patients with type 1 diabetes with severe diabetic retinopathy: a nested case-control study in Brazil

  Patients with severe DR N  =  117 Patients without DR N  =  117 OR (CI) p
N (%) N (%)
HLA-DRB1*
 01:01 6 (2.56) 8 (3.42) 0.74 (0.25–2.18) 0.59
 01:02 5 (2.14) 6 (2.56) 0.83 (0.25–2.76) 0.76
 03:01 68 (29.06) 80 (34.19) 0.79 (0.53–1.16) 0.23
 04:01 8 (3.42) 15 (6.41) 0.52 (0.21–1.24) 0.13
 04:02 13 (5.56) 14 (5.98) 0.92 (0.42–2.01) 0.84
 04:04 8 (3.42) 10 (4.27) 0.79 (0.31–2.05) 0.63
 04:05 35 (14.96) 24 (10.26) 1.54 (0.88–2.68) 0.13
 07:01 18 (7.69) 23 (9.83) 0.76 (0.40–1.46) 0.41
 09:01 4 (1.71) 10 (4.27) 0.39 (0.12–1.26) 0.10
 13:02 15 (6.41) 4 (1.71) 3.94 (1.29–12.05) 0.01
 Others 54 (23.08) 40 (17.09) 1.45 (0.92–2.30) 0.11
HLA-DQA1*
 01:01 g 17 (7.26) 21 (8.97) 0.79 (0.41–1.55) 0.49
 01:02 24 (10.26) 15 (6.41) 1.67 (0.85–3.27) 0.13
 01:03 5 (2.14) 3 (1.28) 1.68 (0.40–7.12) 0.48
 02:01 17 (7.26) 22 (9.40) 0.75 (0.39–1.46) 0.40
 03:01 g 74 (31.62) 77 (32.91) 0.94 (0.64–1.39) 0.77
 04:01 12 (5.13) 6 (2.56) 2.05 (0.76–5.57) 0.14
 04:02 1 (0.43) 0 (0.00)    NA
 05:01 g 82 (35.04) 90 (38.46) 0.86 (0.59–1.26) 0.44
 05:10 2 (0.85) 0 (0.00)    NA
HLA-DQB1*
 02:01 71 (30.34) 81 (34.62) 0.82 (0.56–1.21) 0.32
 02:02 23 (9.83) 35 (14.96) 0.62 (0.35–1.09) 0.09
 03:01 g 22 (9.40) 11 (4.70) 2.10 (1.0–4.44) 0.047
 03:02 60 (25.64) 58 (24.79) 1.05 (0.69–1.59) 0.83
 04:02 11 (4.70) 5 (2.14) 2.26 (0.77–6.61) 0.13
 05:01 17 (7.26) 20 (8.55) 0.84 (0.43–1.64) 0.61
 06:04 10 (4.27) 4 (1.71) 2.57 (0.79–8.30) 0.1
 Others 20 (8.55) 20 (8.55) 1.00 (0.52–1.91) 1
  1. Bold represents statistical significance (p < 0.05)
  2. Rare alleles were included in others
  3. DR diabetic retinopathy; N number of individuals; OR odds ratio; CI confidence interval; NA non applicable