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Table 2 HLA-DRB1*, -DQB1*, and -DQA1* alleles distribution in patients with severe DR and patients without DR

From: Human Leukocyte Antigens class II (HLA II) gene profile from an admixed population of patients with type 1 diabetes with severe diabetic retinopathy: a nested case-control study in Brazil

 

Patients with severe DR N  =  117

Patients without DR N  =  117

OR

(CI)

p

N

(%)

N

(%)

HLA-DRB1*

 01:01

6

(2.56)

8

(3.42)

0.74

(0.25–2.18)

0.59

 01:02

5

(2.14)

6

(2.56)

0.83

(0.25–2.76)

0.76

 03:01

68

(29.06)

80

(34.19)

0.79

(0.53–1.16)

0.23

 04:01

8

(3.42)

15

(6.41)

0.52

(0.21–1.24)

0.13

 04:02

13

(5.56)

14

(5.98)

0.92

(0.42–2.01)

0.84

 04:04

8

(3.42)

10

(4.27)

0.79

(0.31–2.05)

0.63

 04:05

35

(14.96)

24

(10.26)

1.54

(0.88–2.68)

0.13

 07:01

18

(7.69)

23

(9.83)

0.76

(0.40–1.46)

0.41

 09:01

4

(1.71)

10

(4.27)

0.39

(0.12–1.26)

0.10

 13:02

15

(6.41)

4

(1.71)

3.94

(1.29–12.05)

0.01

 Others

54

(23.08)

40

(17.09)

1.45

(0.92–2.30)

0.11

HLA-DQA1*

 01:01 g

17

(7.26)

21

(8.97)

0.79

(0.41–1.55)

0.49

 01:02

24

(10.26)

15

(6.41)

1.67

(0.85–3.27)

0.13

 01:03

5

(2.14)

3

(1.28)

1.68

(0.40–7.12)

0.48

 02:01

17

(7.26)

22

(9.40)

0.75

(0.39–1.46)

0.40

 03:01 g

74

(31.62)

77

(32.91)

0.94

(0.64–1.39)

0.77

 04:01

12

(5.13)

6

(2.56)

2.05

(0.76–5.57)

0.14

 04:02

1

(0.43)

0

(0.00)

  

NA

 05:01 g

82

(35.04)

90

(38.46)

0.86

(0.59–1.26)

0.44

 05:10

2

(0.85)

0

(0.00)

  

NA

HLA-DQB1*

 02:01

71

(30.34)

81

(34.62)

0.82

(0.56–1.21)

0.32

 02:02

23

(9.83)

35

(14.96)

0.62

(0.35–1.09)

0.09

 03:01 g

22

(9.40)

11

(4.70)

2.10

(1.0–4.44)

0.047

 03:02

60

(25.64)

58

(24.79)

1.05

(0.69–1.59)

0.83

 04:02

11

(4.70)

5

(2.14)

2.26

(0.77–6.61)

0.13

 05:01

17

(7.26)

20

(8.55)

0.84

(0.43–1.64)

0.61

 06:04

10

(4.27)

4

(1.71)

2.57

(0.79–8.30)

0.1

 Others

20

(8.55)

20

(8.55)

1.00

(0.52–1.91)

1

  1. Bold represents statistical significance (p < 0.05)
  2. Rare alleles were included in others
  3. DR diabetic retinopathy; N number of individuals; OR odds ratio; CI confidence interval; NA non applicable