Skip to main content

Table 3 Clinical characteristics of diabetes patients, comparison between in-hospital metformin users and non-users

From: Outcome and death risk of diabetes patients with Covid-19 receiving pre-hospital and in-hospital metformin therapies

 

Non-met-group (n = 73) Number (%)

Met-group (n = 115) Number (%)

Pa

Gender

 Female

28 (38.4%)

42 (36.5)

0.80

 Male

45 (61.6%)

73 (63.5%)

 

Age

67 (29–95)

63 (37–92)

0.26

Age class (years)

 29–59

25 (34.2%)

47 (40.9%)

0.44

  ≥ 60

48 (65.8%)

68 (59.1%)

 

Clinical outcome

 Mortality

15 (20.5%)

4 (3.5%)

0.0002

Mortality by gender

 Female

9 (81.8%)

2 (50%)

1

 Male

6 (75.0%)

2 (50%)

 

Mortality by age class

 29–59

1 (6.7%)

0 (0%)

 

  ≥ 60

14 (19.18%)

4 (3.48%)

0.0006

Comorbidities

 Obesity

11 (15.1%)

20 (17.4%)

0.26

 Cardiopathy

19 (26.0%)

22 (19.1%)

0.28

 Hypertension

57 (78.1%)

68 (59.1%)

0.007

 COPD/pneumonia

8 (11.0%)

9 (7.8%)

0.46

 Smoking/former smoking

4 (5.5%)

11(9.6%)

0.41

 Neurological disease

7 (9.6%)

6 (5.2%)

0.25

 CKD

9 (12.3%)

2 (1.7%)

0.004

 Thyroid

9 (12.3%)

15 (13%)

0.89

 Dyslipidemia

33 (45.2%)

37 (32.2%)

0.07

 Neoplasia/immuno

5 (6.8%)

7 (6.1%)

0.83

 Asthma

1 (1.4%)

3 (2.6%)

0.56

 BMI

29.42 ± 5.14

29.24 ± 5.28

0.16

In-hospital clinical characteristics

 NEWS

2 (0–11)

2 (0–9.3)

0.63

 Time of stay in ICU

3 (0–94)

2 (0–41)

0.27

 Time of stay in nursery

6 (0–39)

7 (0–58)

0.54

 Total hospitalization time

10 (3–100)

11 (2–65)

0.57

 Time of MV

0.0 (0–63);

0.0 (0–26)

0.09

 In-hospital metformin therapy

–

115 (100%)

–

 In-hospital max dose of metformin

–

1249.13 ± 578.7

–

 In-hospital time of metformin therapy

–

8.87 ± 9.24;

–

 Pre-hospital metformin therapy

19 (26%)

97 (84.3%)

0.000

 Pre-hospital metformin daily dose

1235.3 ± 597.22

1127.01 ± 629.21

0.51

 In-hospital insulin therapy

18 (24.7%)

43 (37.4%)

0.08

 In-hospital time of insulin therapya

15.5 (1–98)

3 (1–42)

0.019

 Orotracheal intubation

20 (27.4%)

25 (22.5%)

0.45

 Prisma

11 (15.1%)

4 (3.6%)

0.011

 Prone

4 (5.5%)

3 (2.7%)

0.4

 Vasoactive drugs

19 (26%)

18 16.2%

0.1

 CLHO/HCQ

12 (16.9%)

13 (11.3%)

0.27

 Dexamethasone/prednisolone

65 (89.0%)

104 (90.4%)

0.75

  1. COPD, chronic obstructive pulmonary disease; CKD, chronic kidney disease; NEWS/PEWS, National Early Warning Score/Pediatric Early Warning Score; Prisma, prisma hemodialysis machine; Prona, prone position; Neoplasia/immune, Neoplasia/immunosuppression; BMI, body mass index; Time of MV, Time of mechanical ventilation; In-hospital max dose of metformin: In-hospital maximum dose of metformin; CLHO/HCQ, Chloroquine/hydroxychloroquine. atime in days. Bold: p < 0.05
Back to article page

Diabetology & Metabolic Syndrome

ISSN: 1758-5996

Contact us