Skip to main content

Table 3 Subgroup analyses for all fracture and hip fracture according to study design and gender

From: Differences in the roles of types 1 and 2 diabetes in the susceptibility to the risk of fracture: a systematic review and meta-analysis

Outcomes

Factors

Groups

DM type

OR and 95% CI

P value

I2 (%)/PQ statistic

Ratio for OR

P value between T1DM and T2DM

All fracture

Study design

Prospective

T1DM

1.40 (1.18–1.65)

< 0.001

50.6/0.108

1.21 (1.00–1.46)

0.050

T2DM

1.16 (1.07–1.27)

< 0.001

68.9/0.001

Retrospective

T1DM

1.86 (1.36–2.53)

< 0.001

99.0/< 0.001

1.56 (1.09–2.24)

0.015

T2DM

1.19 (0.99–1.43)

0.060

96.6/< 0.001

Gender

Male

T1DM

1.50 (1.33–1.70)

< 0.001

51.2/0.129

1.25 (0.92–1.69)

0.147

T2DM

1.20 (0.91–1.58)

0.200

93.0/< 0.001

Female

T1DM

1.52 (1.17–1.97)

0.002

88.9/< 0.001

1.27 (0.97–1.66)

0.085

T2DM

1.20 (1.12–1.28)

< 0.001

54.2/0.026

Both

T1DM

2.47 (2.36–2.58)

< 0.001

–

1.99 (1.40–2.83)

< 0.001

T2DM

1.24 (0.87–1.75)

0.232

87.8/< 0.001

Hip fracture

Study design

Prospective

T1DM

4.56 (2.49–8.34)

< 0.001

91.5/< 0.001

3.28 (1.76–6.10)

< 0.001

T2DM

1.39 (1.21–1.60)

< 0.001

80.6/< 0.001

Retrospective

T1DM

3.88 (2.68–5.61)

< 0.001

96.0/< 0.001

3.43 (2.35–5.03)

< 0.001

T2DM

1.13 (1.03–1.24)

0.010

89.3/< 0.001

Gender

Male

T1DM

3.95 (2.10–7.43)

< 0.001

95.7/< 0.001

3.95 (2.09–7.46)

< 0.001

T2DM

1.00 (0.93–1.08)

0.946

36.5/0.178

Female

T1DM

4.76 (2.66–8.52)

< 0.001

95.9/< 0.001

3.33 (1.83–6.05)

< 0.001

T2DM

1.43 (1.25–1.64)

< 0.001

88.2/< 0.001

Both

T1DM

2.41 (2.20–2.65)

< 0.001

–

2.15 (1.80–2.58)

< 0.001

T2DM

1.12 (0.96–1.31)

0.136

41.0/0.132