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Table 2 Pooled ORs and 95% CIs of the association between KCNQ1 rs2237892 polymorphism and T2DM

From: Effect of KCNQ1 rs2237892 polymorphism on the predisposition to type 2 diabetes mellitus: An updated meta-analysis

Total and subgroups Studies CC vs CT + TT CC + CT vs TT C VS T
OR 95%CI I2 P OR 95%CI I2 P OR 95%CI I2 P
Total 41/60 1.26 1.14 –1.40 87.2%  < 0.001 1.50 1.34–1.68 66.6%  < 0.001 1.25 1.19 –1.32 86.6%  < 0.001
Ethnicity
 East Asian 30/42 1.39 1.31–1.49 61.4%  < 0.001 1.59 1.50–1.68 0.0% 0.575 1.32 1.27–1.37 69.4%  < 0.001
 Southeast Asian 3/4 1.43 1.20 –1.72 0.00% 0.453 1.79 1.27–2.52 0.0% 0.712 1.30 1.17–1.45 20.0% 0.290
 South Asian 1/2 1,53 0.94–2.48 1.26 0.08–20.27 2.07 1.03 –4.17 64.6% 0.093
 West Asian 3/3 0.64 0.26–1.57 82.3% 0.003 1.50 1.39–1.68 68.5% 0.075 1.25 1.19 –1.32 83.0% 0.003
 Caucasian 2/4 1.00 0.56–1.76 79.0% 0.029 0.44 0.18–1.08 1.19 1.02–1.38 36.7% 0.192
 Other 2/5 0.91 0.52–1.61 43.5% 0.184 0.68 0.27–1.70 0.0% 0.677 1.06 0.90–1.25 75.1% 0.003
Source of control
 HB 17/19 1.25 1.08–1.46 59.2% 0.001 1.68 1.44–1.97 10.6% 0.335 1.24 1.14–1.37 63.4%  < 0.001
 PB 11/24 1.48 1.38–1.59 47.4% 0.040 1.50 1.34–1.68 0.0% 0.984 1.25 1.19–1.32 67.6%  < 0.001
 NR 13/17 1.13 0.87–1.42 94.6%  < 0.001 1.21 0.91–1.62 86.2%  < 0.001 1.16 1.02–1.32 95.0%  < 0.001
Case size
  < 500 21 1.24 1.05–1.46 63.6%  < 0.001 1.77 1.50 –2.08 0.0% 0.483 1.23 1.09–1.38 71.5%  < 0.001
 500 –1000 10 1.13 0.81–1.58 95.3%  < 0.001 1.32 0.91–1.91 88.5%  < 0.001 1.14 0.88–1.48 95.7%  < 0.001
 1001–2000 4 1.41 1.14–1.75 82.4% 0.001 1.44 1.26–1.65 0.0% 0.670 1.25 1.19 –1.32 67.3%  < 0.001
  > 2000 6 1.43 1.33–1.53 58.0% 0.036 1.56 1.41–1.72 35.2% 0.173 1.33 1.27–1.39 80.1%  < 0.001
HWE status
 Yes 36/36 1.36 1.28–1.45 57.3%  < 0.001 1.57 1.48 –1.67 2.9% 0.420 1.32 1.26–1.38 53.2%  < 0.001
 No 5/5 0.95 0.46–1.96 97.8%  < 0.001 0.99 0.45 –2.18 94.0%  < 0.001 1.25 1.19–1.32 98.1%  < 0.001
 NK 0/19 1.25 1.18 –1.34 82.8%  < 0.001