Table 2 Pooled ORs and 95% CIs of the association between KCNQ1 rs2237892 polymorphism and T2DM

Total

41/60

1.26

1.14 –1.40

87.2%

 < 0.001

1.50

1.34–1.68

66.6%

 < 0.001

1.19 –1.32

Ethnicity

 East Asian

30/42

1.39

1.31–1.49

61.4%

 < 0.001

1.59

1.50–1.68

0.0%

0.575

1.27–1.37

 Southeast Asian

3/4

1.43

1.20 –1.72

0.00%

0.453

1.79

1.27–2.52

0.0%

0.712

1.17–1.45

 South Asian

1/2

1,53

0.94–2.48

−

−

1.26

0.08–20.27

–

–

1.03 –4.17

 West Asian

3/3

0.64

0.26–1.57

82.3%

0.003

1.50

1.39–1.68

68.5%

0.075

1.19 –1.32

 Caucasian

2/4

1.00

0.56–1.76

79.0%

0.029

0.44

0.18–1.08

–

–

1.02–1.38

 Other

2/5

0.91

0.52–1.61

43.5%

0.184

0.68

0.27–1.70

0.0%

0.677

0.90–1.25

Source of control

 HB

17/19

1.25

1.08–1.46

59.2%

0.001

1.68

1.44–1.97

10.6%

0.335

1.14–1.37

 PB

11/24

1.48

1.38–1.59

47.4%

0.040

1.50

1.34–1.68

0.0%

0.984

1.19–1.32

 NR

13/17

1.13

0.87–1.42

94.6%

 < 0.001

1.21

0.91–1.62

86.2%

 < 0.001

1.02–1.32

Case size

  < 500

21

1.24

1.05–1.46

63.6%

 < 0.001

1.77

1.50 –2.08

0.0%

0.483

1.09–1.38

 500 –1000

10

1.13

0.81–1.58

95.3%

 < 0.001

1.32

0.91–1.91

88.5%

 < 0.001

0.88–1.48

 1001–2000

4

1.41

1.14–1.75

82.4%

0.001

1.44

1.26–1.65

0.0%

0.670

1.19 –1.32

  > 2000

6

1.43

1.33–1.53

58.0%

0.036

1.56

1.41–1.72

35.2%

0.173

1.27–1.39

HWE status

 Yes

36/36

1.36

1.28–1.45

57.3%

 < 0.001

1.57

1.48 –1.67

2.9%

0.420

1.26–1.38

 No

5/5

0.95

0.46–1.96

97.8%

 < 0.001

0.99

0.45 –2.18

94.0%

 < 0.001

1.19–1.32

 NK

0/19

–

–

–

–

–

–

–

–

1.18 –1.34