Effects of short-term dietary restriction on plasma metabolites and the subcutaneous fat area according to metabolic status in obese individuals: a case–control study

Table 2 Untargeted metabolomic profiling in the metabolic status maintenance group and metabolic status improvement group at 12 weeks

Metabolite	Formula	m/z	Metabolic status maintenance group (n = 17)	Metabolic status improvement group (n = 12)	VIP	p	q
3-Methoxybenzenepropanoic acid	C₁₀H₁₂O₃	181.087	48,483,001 ± 2,436,817	47,524,456 ± 2,472,852	1.090	0.777	0.773
3-Oxodecanoic acid	C₁₀H₁₈O₃	187.133	17,193,428 ± 5,245,147	18,066 ± 6192	1.123	0.053	0.148
4-Aminobutyraldehyde	C₄H₉NO	88.076	731,124,345 ± 52,880,560	521,581,495 ± 28,774,143	1.576	0.005	0.079
4'-Apo-β-carotenal	C₃₅H₄₆O	483.366	178,245,850 ± 29,268,414	281,940,254 ± 20,697,133	8.915	0.024	0.115
Creatine	C₄H₉N₃O₂	132.066	73,998,544 ± 3,083,621	69,558,095 ± 4,435,850	1.867	0.419	0.402
LysoPC (18:4)	C₂₆H₄₆NO₇P	516.308	5,405,106,623 ± 430,811,273	6,055,631,630 ± 237,704,258	4.383	0.711	0.536
MG (0:0/18:2/0:0)	C₂₁H₃₈O₄	355.367	30,656,117,810 ± 1,869,304,399	29,781,442,820 ± 2,257,208,392	2.244	0.616	0.499
N-Arachidonoyl tyrosine	C₂₉H₄₁NO₄	468.311	10,791,398,770 ± 615,655,355	10,063,129,180 ± 816,638,352	1.202	0.303	0.332
Retinyl ester	C₂₀H₃₀O₂	302.245	4,362,841,825 ± 1,329,757,698	426,188 ± 132,349	2.324	0.195	0.266

Bold values indicate statistically significant results
Mean ± SE. Mann–Whitney U test was used to calculate p-values. q-values are the false discovery rate (FDR)-adjusted p-values
VIP variable important in the projection

ISSN: 1758-5996