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Fig. 9 | Diabetology & Metabolic Syndrome

Fig. 9

From: Circ-PNPT1 contributes to gestational diabetes mellitus (GDM) by regulating the function of trophoblast cells through miR-889-3p/PAK1 axis

Fig. 9

Extracellular circ-PNPT1 is packaged into exosomes and can be internalized by trophoblast cells. A Representative TEM images of exosomes from HTR8/SVneo cells treated with HG or not. B Western blot analysis of CD9 and CD63 in exosomes and cell lysate. C qRT-PCR analysis of circ-PNPT1 expression in exosomes isolated from HTR8/SVneo cells treated with HG or not. D qRT-PCR analysis of circ-PNPT1 expression in the cell media of HG-induced HTR8/SVneo cells which were co-cultured with or without GW4869. E qRT-PCR analysis of circ-PNPT1 expression in HTR8/SVneo cells co-cultured with exosomes carrying circ-PNPT1 or PBS. **P < 0.01, ****P < 0.0001

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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