Fig. 8

Circ-PNPT1 leads to trophoblast cell dysfunction via miR-889-3p/PAK1 axis. HTR8/SVneo cells were transfected with si-NC, si-circ-PNPT1, si-circ-PNPT1 + anti-miR-NC, or si-circ-PNPT1 + anti-miR-889-3p, followed by treatment with HG. A, B qRT-PCR and Western blot analysis of PAK1 level in HTR8/SVneo cells. ***P < 0.001, ****P < 0.0001