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Fig. 7 | Diabetology & Metabolic Syndrome

Fig. 7

From: Circ-PNPT1 contributes to gestational diabetes mellitus (GDM) by regulating the function of trophoblast cells through miR-889-3p/PAK1 axis

Fig. 7

MiR-889-3p protects trophoblast cell from HG-induced cell growth and transfer processes inhibition. AF HTR8/SVneo cells were transfected with miR-NC, miR-889-3p, miR-889-3p + pcDNA, or miR-889-3p + PAK1, followed by treatment with HG. A Western blot analysis of PAK1 protein level in HTR8/SVneo cells. B CCK-8 assay for cell viability. C Flow cytometric analysis of cell apoptosis. D, E Transwell assay of cell migration and invasion. F Wound healing assay for cell migration. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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