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Table 4 Results of two different binary logistic regression analyses with prediabetes (versus healthy controls) and Prediabetes-IR versus Prediabetes+IR as dependent variables and the biomarkers as explanatory variables

From: The immune-opioid axis in prediabetes: predicting prediabetes with insulin resistance by plasma interleukin-10 and endomorphin-2 to kappa-opioid receptors ratio

Dichotomies Explanatory variables B SE Wald df p OR 95% CI
Prediabetes/Controls IL-10 0.359 0.128 7.876 1 0.005 1.431 1.114–1.839
zLnβEP 0.316 0.137 5.311 1 0.021 1.372 1.048–1.795
zLnEM2 0.846 0.396 4.569 1 0.033 2.331 1.073–5.063
Prediabetes-IR/Prediabetes+IR IL-10 0.618 0.05 2.505 1 0.043 1.083 0.981–1.195
zLnEM2/KOR 0.555 0.433 4.846 1 0.024 2.611 1.187–3.947
  1. zLn: z-score of the natural logarithm; IL: interleukin; KOR: κ-opioid receptor; MOR: µ-opioid receptor; EM2: Endomorphin-2; βEP: β-endorphin; IR: insulin resistance (HOMA2IR > 2.5)