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Table 4 The association between the insulin response dietary and lifestyle indices and incidence of insulin related disorders after excluding the diabetic patients in the baseline of study

From: The association of insulinemic potential of diet and lifestyle with the risk of insulin-related disorders: a prospective cohort study among participants of Tehran Lipid and Glucose Study

 

Tertiles of ELIH

P_trend

Tertiles of EDIH

P_trend

T1

T2

T3

T1

T2

T3

Hyperinsulinemia

 Median score

1.04

1.28

1.55

 

0.02

0.14

0.37

 

 Case/Total

34/273

59/264

68/258

 

64/261

41/268

57/272

 

 Model 1a

1.00 (Ref.)

2.14 (1.33–3.45)

2.66 (1.66–4.28)

 < 0.001

1.00 (Ref.)

0.55 (0.35–0.88)

0.72 (0.47–1.12)

0.331

 Model 2b

1.00 (Ref.)

2.15 (1.33–3.46)

2.62 (1.62–4.22)

 < 0.001

1.00 (Ref.)

0.56 (0.35–0.89)

0.73 (0.45–1.17)

0.376

 Model 3c

1.00 (Ref.)

2.15 (1.33–3.46)

2.61 (1.62–4.22)

 < 0.001

1.00 (Ref.)

0.56 (0.35–0.89)

0.73 (0.45–1.16)

0.542

Insulin resistance

 Median score

1.03

1.27

1.51

 

0.02

0.15

0.40

 

 Case/Total

40/236

74/234

89/230

 

66/232

64/237

73/236

 

 Model 1a

1.00 (Ref.)

2.26 (1.45–3.52)

2.95 (1.90–4.58)

 < 0.001

1.00 (Ref.)

1.03 (0.68–1.57)

1.22 (0.80–1.84)

0.314

 Model 2b

1.00 (Ref.)

2.25 (1.44–3.51)

2.87 (1.84–4.47)

 < 0.001

1.00 (Ref.)

0.97 (0.63–1.50)

1.10 (0.70–1.74)

0.597

 Model 3c

1.00 (Ref.)

2.24 (1.43–3.50)

2.83 (1.82–4.26)

 < 0.001

1.00 (Ref.)

0.96 (0.62–1.48)

1.10 (0.70–1.73)

0.614

β-cell dysfunction

 Median score

1.09

1.35

1.66

 

0.02

0.15

0.39

 

 Case/Total

107/314

68/314

43/304

 

89/309

64/314

68/317

 

 Model 1a

1.00 (Ref.)

0.51 (0.35–0.73)

0.29 (0.19–0.44)

 < 0.001

1.00 (Ref.)

0.60 (0.41–0.88)

0.76 (0.52–1.11)

0.566

 Model 2b

1.00 (Ref.)

0.51 (0.35–0.74)

0.30 (0.19–0.45)

 < 0.001

1.00 (Ref.)

0.64 (0.43–0.96)

0.84 (0.55–1.27)

0.592

 Model 3c

1.00 (Ref.)

0.52 (0.36–0.76)

0.30 (0.19–0.45)

 < 0.001

1.00 (Ref.)

0.66 (0.44–0.98)

0.84 (0.55–1.27)

0.581

Insulin insensitivity

 Median score

1.03

1.27

1.51

 

0.02

0.15

0.40

 

 Case/Total

40/234

73/233

89/231

 

66/231

64/237

72/235

 

 Model 1a

1.00 (Ref.)

2.23 (1.43–3.48)

2.89 (1.86–4.50)

 < 0.001

1.00 (Ref.)

1.01 (0.67–1.54)

1.17 (0.77–1.78)

0.403

 Model 2b

1.00 (Ref.)

2.23 (1.43–3.49)

2.82 (1.81–4.39)

 < 0.001

1.00 (Ref.)

0.95 (0.61–1.46)

1.04 (0.66–1.63)

0.793

 Model 3c

1.00 (Ref.)

2.31 (1.42–3.48)

2.78 (1.78–4.34)

 < 0.001

1.00 (Ref.)

0.93 (0.60–1.44)

1.03 (0.65–1.62)

0.812

  1. aModel 1: adjusted for age and sex
  2. bModel 2: adjusted for model 1 and energy intake, smoking, education level (for both), body mass index and physical activity (only for EDIH)
  3. cModel 3: adjusted for model 2 and baseline hypertension