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Table 4 The association between the insulin response dietary and lifestyle indices and incidence of insulin related disorders after excluding the diabetic patients in the baseline of study

From: The association of insulinemic potential of diet and lifestyle with the risk of insulin-related disorders: a prospective cohort study among participants of Tehran Lipid and Glucose Study

  Tertiles of ELIH P_trend Tertiles of EDIH P_trend
T1 T2 T3 T1 T2 T3
Hyperinsulinemia
 Median score 1.04 1.28 1.55   0.02 0.14 0.37  
 Case/Total 34/273 59/264 68/258   64/261 41/268 57/272  
 Model 1a 1.00 (Ref.) 2.14 (1.33–3.45) 2.66 (1.66–4.28)  < 0.001 1.00 (Ref.) 0.55 (0.35–0.88) 0.72 (0.47–1.12) 0.331
 Model 2b 1.00 (Ref.) 2.15 (1.33–3.46) 2.62 (1.62–4.22)  < 0.001 1.00 (Ref.) 0.56 (0.35–0.89) 0.73 (0.45–1.17) 0.376
 Model 3c 1.00 (Ref.) 2.15 (1.33–3.46) 2.61 (1.62–4.22)  < 0.001 1.00 (Ref.) 0.56 (0.35–0.89) 0.73 (0.45–1.16) 0.542
Insulin resistance
 Median score 1.03 1.27 1.51   0.02 0.15 0.40  
 Case/Total 40/236 74/234 89/230   66/232 64/237 73/236  
 Model 1a 1.00 (Ref.) 2.26 (1.45–3.52) 2.95 (1.90–4.58)  < 0.001 1.00 (Ref.) 1.03 (0.68–1.57) 1.22 (0.80–1.84) 0.314
 Model 2b 1.00 (Ref.) 2.25 (1.44–3.51) 2.87 (1.84–4.47)  < 0.001 1.00 (Ref.) 0.97 (0.63–1.50) 1.10 (0.70–1.74) 0.597
 Model 3c 1.00 (Ref.) 2.24 (1.43–3.50) 2.83 (1.82–4.26)  < 0.001 1.00 (Ref.) 0.96 (0.62–1.48) 1.10 (0.70–1.73) 0.614
β-cell dysfunction
 Median score 1.09 1.35 1.66   0.02 0.15 0.39  
 Case/Total 107/314 68/314 43/304   89/309 64/314 68/317  
 Model 1a 1.00 (Ref.) 0.51 (0.35–0.73) 0.29 (0.19–0.44)  < 0.001 1.00 (Ref.) 0.60 (0.41–0.88) 0.76 (0.52–1.11) 0.566
 Model 2b 1.00 (Ref.) 0.51 (0.35–0.74) 0.30 (0.19–0.45)  < 0.001 1.00 (Ref.) 0.64 (0.43–0.96) 0.84 (0.55–1.27) 0.592
 Model 3c 1.00 (Ref.) 0.52 (0.36–0.76) 0.30 (0.19–0.45)  < 0.001 1.00 (Ref.) 0.66 (0.44–0.98) 0.84 (0.55–1.27) 0.581
Insulin insensitivity
 Median score 1.03 1.27 1.51   0.02 0.15 0.40  
 Case/Total 40/234 73/233 89/231   66/231 64/237 72/235  
 Model 1a 1.00 (Ref.) 2.23 (1.43–3.48) 2.89 (1.86–4.50)  < 0.001 1.00 (Ref.) 1.01 (0.67–1.54) 1.17 (0.77–1.78) 0.403
 Model 2b 1.00 (Ref.) 2.23 (1.43–3.49) 2.82 (1.81–4.39)  < 0.001 1.00 (Ref.) 0.95 (0.61–1.46) 1.04 (0.66–1.63) 0.793
 Model 3c 1.00 (Ref.) 2.31 (1.42–3.48) 2.78 (1.78–4.34)  < 0.001 1.00 (Ref.) 0.93 (0.60–1.44) 1.03 (0.65–1.62) 0.812
  1. aModel 1: adjusted for age and sex
  2. bModel 2: adjusted for model 1 and energy intake, smoking, education level (for both), body mass index and physical activity (only for EDIH)
  3. cModel 3: adjusted for model 2 and baseline hypertension
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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