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Table 3 The association between the insulin response dietary and lifestyle indices and incidence of insulin related disorders

From: The association of insulinemic potential of diet and lifestyle with the risk of insulin-related disorders: a prospective cohort study among participants of Tehran Lipid and Glucose Study

 

Tertiles of ELIH

P_trend

Tertiles of EDIH

P_trend

T1

T2

T3

T1

T2

T3

Hyperinsulinemia

 Median score

1.04

1.28

1.55

 

0.01

0.14

0.37

 

 Case/Total

36/283

63/283

71/282

 

68/285

45/285

58/285

 

 Model 1a

1.00 (Ref.)

2.05 (1.29–3.26)

2.46 (1.55–3.90)

 < 0.001

1.00 (Ref.)

0.60 (0.38–0.93)

0.74 (0.48–1.14)

0.609

 Model 2b

1.00 (Ref.)

2.06 (1.30–3.28)

2.41 (1.51–3.85)

 < 0.001

1.00 (Ref.)

0.61 (0.38–0.95)

0.75 (0.47–1.19)

0.633

 Model 3c

1.00 (Ref.)

2.07 (1.30–3.29)

2.42 (1.52–3.86)

 < 0.001

1.00 (Ref.)

0.60 (0.38–0.95)

0.75 (0.47–1.19)

0.618

Insulin resistance

 Median score

1.03

1.27

1.51

 

0.02

0.15

0.40

 

 Case/Total

43/242

81/242

93/241

 

74/244

67/243

76/243

 

 Model 1a

1.00 (Ref.)

2.28 (1.48–3.51)

2.80 (1.82–4.29)

 < 0.001

1.00 (Ref.)

0.98 (0.66–1.48)

1.16 (0.78–1.74)

0.434

 Model 2b

1.00 (Ref.)

2.28 (1.48–3.51)

2.74 (1.78–4.21)

 < 0.001

1.00 (Ref.)

0.94 (0.62–1.43)

1.09 (0.70–1.69)

0.495

 Model 3c

1.00 (Ref.)

2.30 (1.49–3.55)

2.71 (1.75–4.18)

 < 0.001

1.00 (Ref.)

0.94 (0.62–1.44)

1.09 (0.70–1.70)

0.475

β-cell dysfunction

 Median score

1.09

1.35

1.66

 

0.02

0.15

0.39

 

 Case/Total

110/319

72/320

53/320

 

100/323

67/322

71/322

 

 Model 1a

1.00 (Ref.)

0.51 (0.35–0.74)

0.31 (0.20–0.46)

 < 0.001

1.00 (Ref.)

0.57 (0.39–0.83)

0.70 (0.48–1.01)

0.229

 Model 2b

1.00 (Ref.)

0.51 (0.35–0.75)

0.32 (0.21–0.48)

 < 0.001

1.00 (Ref.)

0.60 (0.41–0.88)

0.76 (0.51–1.15)

0.430

 Model 3c

1.00 (Ref.)

0.52 (0.36–0.76)

0.30 (0.19–0.45)

 < 0.001

1.00 (Ref.)

0.60 (0.40–0.89)

0.79 (0.52–1.20)

0.437

Insulin insensitivity

 Median score

1.03

1.27

1.51

 

0.02

0.15

0.40

 

 Case/Total

43/240

80/241

93/242

 

74/243

67/243

75/242

 

 Model 1a

1.00 (Ref.)

2.26 (1.47–3.47)

2.75 (1.79–4.21)

 < 0.001

1.00 (Ref.)

0.96 (0.64–1.45)

1.12 (0.75–1.68)

0.497

 Model 2b

1.00 (Ref.)

2.26 (1.47–3.49)

2.69 (1.75–4.13)

 < 0.001

1.00 (Ref.)

0.92 (0.60–1.39)

1.03 (0.66–1.59)

0.803

 Model 3c

1.00 (Ref.)

2.28 (1.48–3.53)

2.65 (1.72–4.10)

 < 0.001

1.00 (Ref.)

0.92 (0.60–1.40)

1.03 (0.66–1.61)

0.796

  1. aModel 1: adjusted for age and sex
  2. bModel 2: adjusted for model 1 and energy intake, smoking, education level (for both), body mass index and physical activity (only for EDIH)
  3. cModel 3: adjusted for model 2 and baseline diabetes and hypertension