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Table 3 The association between the insulin response dietary and lifestyle indices and incidence of insulin related disorders

From: The association of insulinemic potential of diet and lifestyle with the risk of insulin-related disorders: a prospective cohort study among participants of Tehran Lipid and Glucose Study

  Tertiles of ELIH P_trend Tertiles of EDIH P_trend
T1 T2 T3 T1 T2 T3
Hyperinsulinemia
 Median score 1.04 1.28 1.55   0.01 0.14 0.37  
 Case/Total 36/283 63/283 71/282   68/285 45/285 58/285  
 Model 1a 1.00 (Ref.) 2.05 (1.29–3.26) 2.46 (1.55–3.90)  < 0.001 1.00 (Ref.) 0.60 (0.38–0.93) 0.74 (0.48–1.14) 0.609
 Model 2b 1.00 (Ref.) 2.06 (1.30–3.28) 2.41 (1.51–3.85)  < 0.001 1.00 (Ref.) 0.61 (0.38–0.95) 0.75 (0.47–1.19) 0.633
 Model 3c 1.00 (Ref.) 2.07 (1.30–3.29) 2.42 (1.52–3.86)  < 0.001 1.00 (Ref.) 0.60 (0.38–0.95) 0.75 (0.47–1.19) 0.618
Insulin resistance
 Median score 1.03 1.27 1.51   0.02 0.15 0.40  
 Case/Total 43/242 81/242 93/241   74/244 67/243 76/243  
 Model 1a 1.00 (Ref.) 2.28 (1.48–3.51) 2.80 (1.82–4.29)  < 0.001 1.00 (Ref.) 0.98 (0.66–1.48) 1.16 (0.78–1.74) 0.434
 Model 2b 1.00 (Ref.) 2.28 (1.48–3.51) 2.74 (1.78–4.21)  < 0.001 1.00 (Ref.) 0.94 (0.62–1.43) 1.09 (0.70–1.69) 0.495
 Model 3c 1.00 (Ref.) 2.30 (1.49–3.55) 2.71 (1.75–4.18)  < 0.001 1.00 (Ref.) 0.94 (0.62–1.44) 1.09 (0.70–1.70) 0.475
β-cell dysfunction
 Median score 1.09 1.35 1.66   0.02 0.15 0.39  
 Case/Total 110/319 72/320 53/320   100/323 67/322 71/322  
 Model 1a 1.00 (Ref.) 0.51 (0.35–0.74) 0.31 (0.20–0.46)  < 0.001 1.00 (Ref.) 0.57 (0.39–0.83) 0.70 (0.48–1.01) 0.229
 Model 2b 1.00 (Ref.) 0.51 (0.35–0.75) 0.32 (0.21–0.48)  < 0.001 1.00 (Ref.) 0.60 (0.41–0.88) 0.76 (0.51–1.15) 0.430
 Model 3c 1.00 (Ref.) 0.52 (0.36–0.76) 0.30 (0.19–0.45)  < 0.001 1.00 (Ref.) 0.60 (0.40–0.89) 0.79 (0.52–1.20) 0.437
Insulin insensitivity
 Median score 1.03 1.27 1.51   0.02 0.15 0.40  
 Case/Total 43/240 80/241 93/242   74/243 67/243 75/242  
 Model 1a 1.00 (Ref.) 2.26 (1.47–3.47) 2.75 (1.79–4.21)  < 0.001 1.00 (Ref.) 0.96 (0.64–1.45) 1.12 (0.75–1.68) 0.497
 Model 2b 1.00 (Ref.) 2.26 (1.47–3.49) 2.69 (1.75–4.13)  < 0.001 1.00 (Ref.) 0.92 (0.60–1.39) 1.03 (0.66–1.59) 0.803
 Model 3c 1.00 (Ref.) 2.28 (1.48–3.53) 2.65 (1.72–4.10)  < 0.001 1.00 (Ref.) 0.92 (0.60–1.40) 1.03 (0.66–1.61) 0.796
  1. aModel 1: adjusted for age and sex
  2. bModel 2: adjusted for model 1 and energy intake, smoking, education level (for both), body mass index and physical activity (only for EDIH)
  3. cModel 3: adjusted for model 2 and baseline diabetes and hypertension
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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