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Table 2 Islet β cell function indexes of the study participants according to the quartiles of serum ADA levels

From: Inverse relationship between serum adenosine deaminase levels and islet beta cell function in patients with type 2 diabetes

Variables Total Q1 Q2 Q3 Q4 p value
ADA (U/L) 13.6 (11.1–16.9) 9.5 (8.5–10.3) 12.4 (12.4–13.1) 15.0 (14.3–16.0) 19.7 (18.1–21.7)  < 0.001
 n 1573 396 399 388 390
Glu0 (mmol/L) 11.39 ± 3.54 10.05 ± 3.32 11.29 ± 3.24 11.43 ± 3.39 12.83 ± 3.66  < 0.001
Glu30 (mmol/L) 11.99 ± 2.75 11.71 ± 2.55 12.06 ± 2.68 12.05 ± 2.87 12.15 ± 2.88 0.024
Glu60 (mmol/L) 15.33 ± 3.34 15.02 ± 3.26 15.27 ± 3.22 15.37 ± 3.38 15.66 ± 3.47 0.007
Glu120 (mmol/L) 16.53 ± 4.11 15.30 ± 4.21 16.25 ± 3.90 16.90 ± 3.99 17.68 ± 3.98  < 0.001
Glu180 (mmol/L) 12.67 ± 4.23 11.06 ± 4.00 12.28 ± 4.11 13.18 ± 4.13 14.19 ± 4.05  < 0.001
CP0 (ng/mL) 1.17 (0.78–1.75) 1.26 (0.83–1.75) 1.15 (0.74–1.75) 1.18 (0.74–1.82) 1.11 (0.80–1/69) 0.543
CP30 (ng/mL) 2.02 (1.36–2.89) 2.13 (1.49–3.12) 2.01 (1.34–2.90) 2.07 (1.33–2.87) 1.90 (1.25–2.70) 0.008
CP60 (ng/mL) 3.02 (2.04–4.38) 3.28 (2.35–4.64) 3.06 (2.07–4.46) 2.90 (2.05–4.38) 2.79 (1.83–3.86)  < 0.001
CP120 (ng/mL) 4.20 (2.94–5.98) 4.50 (3.16–6.26) 4.19 (2.83–6.02) 4.18 (2.93–5.99) 3.83 (2.71–5.55) 0.003
CP180 (ng/mL) 5.28 (2.72–5.28) 3.85 (2.74–5.36) 3.69 (2.65–5.10) 3.79 (2.79–5.39) 3.73 (2.65–5.25) 0.805
 ISHOMA-cp 1.79 (1.20–2.52) 1.95 (1.37–2.72) 1.82 (1.24–2.58) 1.86 (1.16–2.56) 1.56 (1.06–2.33)  < 0.001
 ISIM-cp 456.62 (328.50–619.82) 484.06 (355.65–646.62) 467.68 (331.12–620.50) 450.20 (320.57–622.24) 425.43 (306.25–563.45) 0.001
 AUCcp 9.84 (6.93–13.70) 10.64 (7.47–14.31) 9.74 (6.84–13.96) 9.88 (6.92–14.01) 9.30 (6.42–12.73) 0.005
 AUCglu 41.96 ± 9.06 39.48 ± 8.92 41.47 ± 8.48 42.67 ± 9.02 44.28 ± 9.15  < 0.001
 AUCcp/glu 0.23 (0.15–0.35) 0.27 (0.18–0.39) 0.23 (0.15–0.34) 0.23 (0.14–0.35) 0.20 (0.14–0.30)  < 0.001
 ISSI2cp 100.24 (70.43–142.99) 121.26 (84.84–178.36) 100.48 (73.23–138.89) 96.67 (69.63–140.94) 81.79 (60.18–116.89)  < 0.001