From: Increased serum asprosin is correlated with diabetic nephropathy
Characteristics | Univariate logistic regression | Multiple logistic regression | ||
---|---|---|---|---|
OR (95% CI) | P | OR (95% CI) | P | |
Age (years) | 1.009 (0.986–1.031) | 0.453 | – | – |
Gender (M/F) | 1.147 (0.666–1.973) | 0.622 | – | – |
Duration (years) | 1.672 (1.404–1.991) | < 0.001 | 1.599 (1.318–1.941) | < 0.001 |
BMI (kg/m2) | 0.997 (0.926–1.074) | 0.94 | – | – |
SBP (mmHg) | 1.022 (1.01–1.034) | < 0.001 | 1.012 (0.988–1.036) | 0.332 |
DBP (mmHg) | 1.024 (1.006–1.043) | 0.011 | 1.008 (0.98–1.038) | 0.572 |
HbA1c (%) | 1.094 (0.898–1.333) | 0.372 | – | – |
TG (mmol/L) | 1.116 (0.9–1.384) | 0.316 | – | – |
TC (mmol/L) | 1.451 (1.104–1.907) | 0.008 | 1.845 (0.581–5.861) | 0.299 |
HDL-C (mmol/L) | 1.782 (0.575–5.519) | 0.317 | – | – |
LDL-C (mmol/L) | 1.525 (1.098–2.118) | 0.012 | 0.659 (0.163–2.668) | 0.559 |
BUN (nmol/L) | 1.326 (1.142–1.539) | < 0.001 | 1.301 (1.02–1.661) | 0.034 |
Cr (μmol/L) | 1.015 (1.004–1.026) | 0.008 | 0.995 (0.974–1.016) | 0.639 |
UA (μmol/L) | 1.002 (0.999–1.005) | 0.267 | – | – |
GFR (mL/min/1.73 m2) | 0.991 (0.984–0.999) | 0.028 | 1.005 (0.993–1.017) | 0.397 |
Asprosin (ng/mL) | 1.242 (1.142–1.35) | < 0.001 | 1.183 (1.064–1.315) | 0.002 |
Treatment | ||||
Metformin (n, %) | 0.718 (0.398–1.295) | 0.271 | – | – |
Acarbose (n, %) | 0.975 (0.567–1.677) | 0.927 | – | – |
Sulfonylureas (n, %) | 0.919 (0.524–1.611) | 0.769 | – | – |
DPP-IV inhibitor (n, %) | 0.794 (0.461–1.369) | 0.407 | – | – |
Insulin (n, %) | 0.883 (0.505–1.544) | 0.663 | – | – |
Statin (n, %) | 1.269 (0.737–2.186) | 0.39 | – | – |
CCB (n, %) | 2.71 (1.507–4.874) | 0.001 | 1.023 (0.382–2.736) | 0.964 |
ACEI/ARB (n, %) | 3.056 (1.718–5.436) | < 0.001 | 1.348 (0.508–3.573) | 0.549 |